Hypertension in Coarctation of the Aorta: Challenges in Diagnosis in Children

Trisha V. Vigneswaran, Manish D. Sinha, Israel Valverde, John M. Simpson, Marietta Charakida*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    30 Citations (Scopus)


    Evidence indicates that patients with coarctation of the aorta (COA) suffer from increased cardiovascular morbidity and mortality in later life despite successful repair of COA in childhood. Systolic arterial hypertension is common, presenting in up to one-third of patients, and is regarded as the main driver of premature cardiovascular events in this group of patients. In this review, we discuss the prevalence and pathophysiology of hypertension in children following successful COA repair with no residual arch obstruction. The challenges in accurate blood pressure assessment at this early phase are considered and non-invasive measures of central blood pressure are discussed. Although the pathways for investigations in adults are well defined, we highlight the need to address the issues of cardiovascular surveillance in children and describe techniques which can provide complementary information for cardiovascular assessment in this group of patients such that timely treatment can occur.

    Original languageEnglish
    JournalPediatric Cardiology
    Issue number1
    Early online date17 Oct 2017
    Publication statusPublished - 1 Jan 2018


    • Arterial stiffness
    • Central blood pressure
    • Coarctation of the aorta
    • Hypertension
    • Paediatric
    • Vasculopathy


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