Hypoxia imaging using PET and SPECT: the effects of anesthetic and carrier gas on [Cu]-ATSM, [Tc]-HL91 and [F]-FMISO tumor hypoxia accumulation

Veerle Kersemans, Bart Cornelissen, Rebekka Hueting, Matthew Tredwell, Kamila Hussien, Philip D Allen, Nadia Falzone, Sally A Hill, Jonathan R Dilworth, Veronique Gouverneur, Ruth J Muschel, Sean C Smart

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32 Citations (Scopus)

Abstract

Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia.
Original languageEnglish
Article numbere25911
JournalPLoS ONE
Volume6
Issue number11
DOIs
Publication statusPublished - 2011

Keywords

  • Adenocarcinoma
  • Anesthesia
  • Animals
  • Anoxia
  • Copper Radioisotopes
  • Female
  • Fluorine Radioisotopes
  • Gases
  • Mice
  • Mice, Inbred CBA
  • Misonidazole
  • Muscles
  • Neoplasms, Experimental
  • Organometallic Compounds
  • Organotechnetium Compounds
  • Oxygen
  • Positron-Emission Tomography
  • Radiation-Sensitizing Agents
  • Radiopharmaceuticals
  • Thiosemicarbazones
  • Tissue Distribution
  • Tomography, Emission-Computed, Single-Photon

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