Hypoxia in head and neck cancer

Mahvash Tavassoli; Yae Eun Suh

doi:10.1007/978-94-024-1084-6_3

Hypoxia in head and neck cancer

Mahvash Tavassoli, Yae Eun Suh^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Head and neck cancer is the sixth most common malignancy worldwide and a major cause of death from cancer, with a median 5-year survival of around 50% (Suh et al. 2014). Over 90% are squamous cell carcinomas arising from the epithelial cells that line the mucosal surfaces of the head and neck. Tumour hypoxia is an important negative prognostic factor for head and neck squamous cell carcinomas (HNSCC), associated with resistance to radiotherapy and decreased overall survival (Bittner and Grosu 2013). Therefore, tumour hypoxia is an important phenomenon in the management of HNSCC and has been the focus of studies to improve treatment response for many years. This chapter aims to discuss some of the key mechanisms affected by tumour hypoxia and review strategies under investigation towards better detection and modulation of tumour hypoxia in order to improve treatment response and survival of head and neck cancer patients.

Original language	English
Title of host publication	Squamous Cell Carcinoma
Subtitle of host publication	Molecular Therapeutic Targets
Publisher	Springer Netherlands
Pages	59-95
Number of pages	37
ISBN (Electronic)	9789402410846
ISBN (Print)	9789402410839
DOIs	https://doi.org/10.1007/978-94-024-1084-6_3
Publication status	Published - 1 Jan 2017

Keywords

Endoplasmic reticulum stress
Formalin fixed paraffin embed
Hypoxic tumour
Unfolded protein response
Vascular endothelial growth factor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-94-024-1084-6_3

Cite this

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abstract = "Head and neck cancer is the sixth most common malignancy worldwide and a major cause of death from cancer, with a median 5-year survival of around 50% (Suh et al. 2014). Over 90% are squamous cell carcinomas arising from the epithelial cells that line the mucosal surfaces of the head and neck. Tumour hypoxia is an important negative prognostic factor for head and neck squamous cell carcinomas (HNSCC), associated with resistance to radiotherapy and decreased overall survival (Bittner and Grosu 2013). Therefore, tumour hypoxia is an important phenomenon in the management of HNSCC and has been the focus of studies to improve treatment response for many years. This chapter aims to discuss some of the key mechanisms affected by tumour hypoxia and review strategies under investigation towards better detection and modulation of tumour hypoxia in order to improve treatment response and survival of head and neck cancer patients.",

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N2 - Head and neck cancer is the sixth most common malignancy worldwide and a major cause of death from cancer, with a median 5-year survival of around 50% (Suh et al. 2014). Over 90% are squamous cell carcinomas arising from the epithelial cells that line the mucosal surfaces of the head and neck. Tumour hypoxia is an important negative prognostic factor for head and neck squamous cell carcinomas (HNSCC), associated with resistance to radiotherapy and decreased overall survival (Bittner and Grosu 2013). Therefore, tumour hypoxia is an important phenomenon in the management of HNSCC and has been the focus of studies to improve treatment response for many years. This chapter aims to discuss some of the key mechanisms affected by tumour hypoxia and review strategies under investigation towards better detection and modulation of tumour hypoxia in order to improve treatment response and survival of head and neck cancer patients.

AB - Head and neck cancer is the sixth most common malignancy worldwide and a major cause of death from cancer, with a median 5-year survival of around 50% (Suh et al. 2014). Over 90% are squamous cell carcinomas arising from the epithelial cells that line the mucosal surfaces of the head and neck. Tumour hypoxia is an important negative prognostic factor for head and neck squamous cell carcinomas (HNSCC), associated with resistance to radiotherapy and decreased overall survival (Bittner and Grosu 2013). Therefore, tumour hypoxia is an important phenomenon in the management of HNSCC and has been the focus of studies to improve treatment response for many years. This chapter aims to discuss some of the key mechanisms affected by tumour hypoxia and review strategies under investigation towards better detection and modulation of tumour hypoxia in order to improve treatment response and survival of head and neck cancer patients.

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KW - Unfolded protein response

KW - Vascular endothelial growth factor

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Hypoxia in head and neck cancer

Abstract

Keywords

UN SDGs

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