Ictal EEG fractal dimension in ECT predicts outcome at 2 weeks in schizophrenia

Hulegar A Abhishekh, Jagadisha Thirthalli, Anusha Manjegowda, Vivek H Phutane, Kesavan Muralidharan, Bangalore N Gangadhar

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Studies of electroconvulsive therapy (ECT) have found an association between ictal electroencephalographic (EEG) measures and clinical outcome in depression. Such studies are lacking in schizophrenia. Consenting schizophrenia patients receiving ECT were assessed using the Brief Psychiatric Rating Scale (BPRS) before and 2 weeks after the start of ECT. The patients' seizure was monitored using EEG. In 26 patients, completely artifact-free EEG derived from the left frontal-pole (FP1) channel and electrocardiography (ECG) were available. The fractal dimension (FD) was computed to assess 4-s EEG epochs, and the maximal value from the earliest ECT session (2nd, 3rd or 4th) was used for analysis. There was a significant inverse correlation between the maximum FD and the total score following 6th ECT. An inverse Inverse correlation was also observed between the maximum FD and the total number of ECTs administered as well as the maximum heart rate (HR) and BPRS scores following 6th ECT. In patients with schizophrenia greater intensity of seizures (higher FD) during initial sessions of ECT is associated with better response at the end of 2 weeks.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalPsychiatry Research
Issue number2
Publication statusPublished - 30 Sept 2013


  • Adult
  • Brain Waves
  • Brief Psychiatric Rating Scale
  • Chi-Square Distribution
  • Electroconvulsive Therapy
  • Electroencephalography
  • Female
  • Humans
  • Male
  • Predictive Value of Tests
  • Schizophrenia
  • Severity of Illness Index
  • Treatment Outcome
  • Young Adult


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