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Ictal source imaging and electroclinical correlation in self-limited epilepsy with centrotemporal spikes

Research output: Contribution to journalArticle

Jørgen Alving ; Martin Fabricius ; Ivana Rosenzweig ; Sándor Beniczky

Original languageEnglish
JournalSeizure
Early online date14 Sep 2017
DOIs
StateE-pub ahead of print - 14 Sep 2017

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Abstract

Purpose: To elucidate the localization of ictal EEG activity, and correlate it to semiological features in self-limited epilepsy with centrotemporal spikes (formerly called “benign epilepsy with centrotemporal spikes”).

Methods: We have performed ictal electric source imaging, and we analysed electroclinical correlations in three patients with self-limited epilepsy with centrotemporal spikes.

Results: The source of the evolving rhythmic ictal activity (9.7-13.5 Hz) localized to the operculo-insular area. The rhythmic EEG activity was time-locked to the contralateral focal motor seizure manifestation: facial rhythmic myoclonic jerks, with the same frequency as the analysed ictal rhythm. In all three patients, the seizures had fluctuating course with pauses of clinical and electrographic seizure activity, ranging from 0.4 to 7 seconds.

Conclusion: Source imaging of ictal EEG activity in patients with self-limited epilepsy with centrotemporal spikes showed activation of the operculo-insular area, time-locked to the contralateral focal myoclonic jerks. Fragmented seizure dynamics, with fluctuating course, previously described as a hallmark in patients with psychogenic non-epileptic seizures, can occur in rolandic seizures.

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