Identification of a candidate gene for astigmatism

Margarida C Lopes, Pirro G Hysi, Virginie J M Verhoeven, Stuart Macgregor, Alex W Hewitt, Grant W Montgomery, Phillippa Cumberland, Johannes R Vingerling, Terri L Young, Cornelia M van Duijn, Ben Oostra, Andre G Uitterlinden, Jugnoo S Rahi, David A Mackey, Caroline C W Klaver, Toby Andrew, Christopher J Hammond

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Astigmatism is a common refractive error that reduces vision, where the curvature and refractive power of the cornea in one meridian are less than those of the perpendicular axis. It is a complex trait likely to be influenced by both genetic and environmental factors. Twin studies of astigmatism have found approximately 60% of phenotypic variance is explained by genetic factors. This study aimed to identify susceptibility loci for astigmatism.
Original languageEnglish
Pages (from-to)1260-7
Number of pages8
JournalInvestigative Ophthalmology & Visual Science
Issue number2
Publication statusPublished - 2013


  • Environment
  • Young Adult
  • Polymorphism, Single Nucleotide
  • Homeodomain Proteins
  • Humans
  • Aged
  • Astigmatism
  • Great Britain
  • Genome-Wide Association Study
  • Registries
  • Phenotype
  • Genotype
  • Chromosomes, Human, Pair 2
  • Aged, 80 and over
  • Adult
  • Middle Aged
  • Australia
  • Genetic Predisposition to Disease
  • Netherlands
  • Adolescent
  • Male
  • Female


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