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Identification of neurobehavioural symptom groups based on shared brain mechanisms

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Identification of neurobehavioural symptom groups based on shared brain mechanisms. / IMAGEN Consortium.

In: Nature Human Behaviour, Vol. 3, No. 12, 01.12.2019, p. 1306-1318.

Research output: Contribution to journalArticle

Harvard

IMAGEN Consortium 2019, 'Identification of neurobehavioural symptom groups based on shared brain mechanisms', Nature Human Behaviour, vol. 3, no. 12, pp. 1306-1318. https://doi.org/10.1038/s41562-019-0738-8

APA

IMAGEN Consortium (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 3(12), 1306-1318. https://doi.org/10.1038/s41562-019-0738-8

Vancouver

IMAGEN Consortium. Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour. 2019 Dec 1;3(12):1306-1318. https://doi.org/10.1038/s41562-019-0738-8

Author

IMAGEN Consortium. / Identification of neurobehavioural symptom groups based on shared brain mechanisms. In: Nature Human Behaviour. 2019 ; Vol. 3, No. 12. pp. 1306-1318.

Bibtex Download

@article{c27dbc8618a04512897590dc2327f6be,
title = "Identification of neurobehavioural symptom groups based on shared brain mechanisms",
abstract = "Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.",
author = "{IMAGEN Consortium} and Alex Ing and S{\"a}mann, {Philipp G.} and Congying Chu and Nicole Tay and Francesca Biondo and Gabriel Robert and Tianye Jia and Thomas Wolfers and Sylvane Desrivi{\`e}res and Tobias Banaschewski and Bokde, {Arun L.W.} and Uli Bromberg and Christian B{\"u}chel and Patricia Conrod and Tahmine Fadai and Herta Flor and Vincent Frouin and Hugh Garavan and Spechler, {Philip A.} and Penny Gowland and Yvonne Grimmer and Andreas Heinz and Bernd Ittermann and Viola Kappel and Martinot, {Jean Luc} and Andreas Meyer-Lindenberg and Sabina Millenet and Frauke Nees and {van Noort}, Betteke and Orfanos, {Dimitri Papadopoulos} and Martinot, {Marie Laure Paill{\`e}re} and Jani Penttil{\"a} and Luise Poustka and Quinlan, {Erin Burke} and Smolka, {Michael N.} and Argyris Stringaris and Maren Struve and Veer, {Ilya M.} and Henrik Walter and Robert Whelan and Andreassen, {Ole A.} and Ingrid Agartz and Herv{\'e} Lemaitre and Barker, {Edward D.} and John Ashburner and Elisabeth Binder and Jan Buitelaar and Andre Marquand and Robbins, {Trevor W.} and Gunter Schumann",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41562-019-0738-8",
language = "English",
volume = "3",
pages = "1306--1318",
journal = "Nature Human Behaviour",
issn = "2397-3374",
publisher = "Nature Publishing Group",
number = "12",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Identification of neurobehavioural symptom groups based on shared brain mechanisms

AU - IMAGEN Consortium

AU - Ing, Alex

AU - Sämann, Philipp G.

AU - Chu, Congying

AU - Tay, Nicole

AU - Biondo, Francesca

AU - Robert, Gabriel

AU - Jia, Tianye

AU - Wolfers, Thomas

AU - Desrivières, Sylvane

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Fadai, Tahmine

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Spechler, Philip A.

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Kappel, Viola

AU - Martinot, Jean Luc

AU - Meyer-Lindenberg, Andreas

AU - Millenet, Sabina

AU - Nees, Frauke

AU - van Noort, Betteke

AU - Orfanos, Dimitri Papadopoulos

AU - Martinot, Marie Laure Paillère

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Quinlan, Erin Burke

AU - Smolka, Michael N.

AU - Stringaris, Argyris

AU - Struve, Maren

AU - Veer, Ilya M.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Andreassen, Ole A.

AU - Agartz, Ingrid

AU - Lemaitre, Hervé

AU - Barker, Edward D.

AU - Ashburner, John

AU - Binder, Elisabeth

AU - Buitelaar, Jan

AU - Marquand, Andre

AU - Robbins, Trevor W.

AU - Schumann, Gunter

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

AB - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case–control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

UR - http://www.scopus.com/inward/record.url?scp=85076447002&partnerID=8YFLogxK

U2 - 10.1038/s41562-019-0738-8

DO - 10.1038/s41562-019-0738-8

M3 - Article

C2 - 31591521

AN - SCOPUS:85076447002

VL - 3

SP - 1306

EP - 1318

JO - Nature Human Behaviour

JF - Nature Human Behaviour

SN - 2397-3374

IS - 12

ER -

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