Identification of synergistic signals initiating inner ear development

TY - JOUR

T1 - Identification of synergistic signals initiating inner ear development

AU - Ladher, R K

AU - Anakwe, K U

AU - Gurney, A L

AU - Schoenwolf, G C

AU - Francis-West, P H

PY - 2000/12/8

Y1 - 2000/12/8

N2 - Tissue manipulation experiments in amphibians more than 50 years ago showed that induction of the inner ear requires two signals: a mesodermal signal followed by a neural signal. However, the molecules mediating this process have remained elusive. We present evidence for mesodermal initiation of otic development in higher Vertebrates and show that the mesoderm can direct terminal differentiation of the inner ear in rostral ectoderm. Furthermore, we demonstrate the synergistic interactions of the extracellular polypeptide ligands FGF-19 and Wnt-8c as mediators of mesodermal and neural signals, respectively, initiating inner ear development.

AB - Tissue manipulation experiments in amphibians more than 50 years ago showed that induction of the inner ear requires two signals: a mesodermal signal followed by a neural signal. However, the molecules mediating this process have remained elusive. We present evidence for mesodermal initiation of otic development in higher Vertebrates and show that the mesoderm can direct terminal differentiation of the inner ear in rostral ectoderm. Furthermore, we demonstrate the synergistic interactions of the extracellular polypeptide ligands FGF-19 and Wnt-8c as mediators of mesodermal and neural signals, respectively, initiating inner ear development.

UR - http://www.scopus.com/inward/record.url?scp=0034623810&partnerID=8YFLogxK

U2 - 10.1126/science.290.5498.1965

DO - 10.1126/science.290.5498.1965

M3 - Article

SN - 1095-9203

VL - 290

SP - 1965

EP - 1967

JO - Science

JF - Science

IS - 5498

ER -