Identifying novel therapeutic targets for diabetes through improved understanding of islet adhesion receptors

Oladapo E Olaniru; Shanta J Persaud

doi:10.1016/j.coph.2018.07.009

Identifying novel therapeutic targets for diabetes through improved understanding of islet adhesion receptors

Oladapo E Olaniru, Shanta J Persaud

Diabetes

Department of Diabetes, School of Life Course Sciences, King's College London, Guy's Campus, London SE1 1UL, UK. Electronic address: [email protected].
Department of Diabetes, School of Life Course Sciences, King's College London, Guy's Campus, London SE1 1UL, UK.

Research output: Contribution to journal › Review article › peer-review

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Abstract

Adhesion receptors are transmembrane proteins that mediate cell-cell and cell-matrix communications. In addition to their adhesive role in maintaining islet architecture, they are also important for promoting islet cell survival, proliferation and secretory function. Their capacity for improving β-cell mass and insulin secretion suggest that they may be suitable targets for pharmacological intervention, and their interactions with extracellular matrix proteins hold promise in improving islet transplantation outcomes. In this review, we have focused on integrins, cadherins and adhesion GPCRs, and highlight recent advances in their roles in islet function and discuss whether they could be targeted for diabetes therapy.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	43
Early online date	4 Aug 2018
DOIs	https://doi.org/10.1016/j.coph.2018.07.009
Publication status	Published - Dec 2018

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10.1016/j.coph.2018.07.009

Identifying novel therapeutic targets_OLANIRU_Publishedonline4August2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 455 KBLicence: CC BY-NC-ND

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AB - Adhesion receptors are transmembrane proteins that mediate cell-cell and cell-matrix communications. In addition to their adhesive role in maintaining islet architecture, they are also important for promoting islet cell survival, proliferation and secretory function. Their capacity for improving β-cell mass and insulin secretion suggest that they may be suitable targets for pharmacological intervention, and their interactions with extracellular matrix proteins hold promise in improving islet transplantation outcomes. In this review, we have focused on integrins, cadherins and adhesion GPCRs, and highlight recent advances in their roles in islet function and discuss whether they could be targeted for diabetes therapy.

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JF - Current Opinion in Pharmacology

ER -

Identifying novel therapeutic targets for diabetes through improved understanding of islet adhesion receptors

Abstract

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