Identifying Subgroups and Novel Brain-Behavior Associations in Adolescents Who were Born Very Preterm Using Bi-clustering Approaches

TY - CONF

T1 - Identifying Subgroups and Novel Brain-Behavior Associations in Adolescents Who were Born Very Preterm Using Bi-clustering Approaches

AU - Gupta, Cota Navin

AU - Hadaya, Laila

AU - Nosarti, Chiara

N1 - Publisher Copyright: © 2023 IEEE.

PY - 2023

Y1 - 2023

N2 - Here we apply Bi-clustered Independent Component Analysis (B-ICA), a data driven two-dimensional clustering algorithm, on three-dimensional T1-weighted magnetic resonance images of 126 adolescents born very preterm (VPT; < 33 weeks of gestation; mean age=15.29 years; standard deviation=0.58). Two components of interest covering regions of insula and hippocampus showing persisting structural alterations following very preterm birth were chosen, based on previous literature. Corresponding component loadings were sorted using the positive or negative method as suggested by the N-way bi-clustering (n-BIC) algorithm. The association between component loadings and participants' total scores on the Rutter Parents Scale (RPS), a scale measuring emotional and conduct difficulties, was studied in three data- driven subgroups. Loadings of subgroup Sinter (n=32), weighted on both insula and hippocampus imaging components, correlated with RPS Total scores (r=-0.458; p=0.008). Subgroup S1 (n=29), heavily weighted on the insula component, did not show any association between regional brain volume and behavioral outcome. However, for the same S1 subgroup, loadings on the hippocampal component correlated with RPS Total scores (r =-0.61; p=3.43e-4). No significant associations between regional brain volume and behavioral outcome were observed for subgroup S2 (n=34). These results suggest that distinct subgroups of VPT adolescents with similarly increased emotional and conduct problems may have differential underlying brain mechanisms implicating different parts of large-scale emotional and cognitive systems. This study enables interpretation of the neurodevelopmental sequelae in VPT by characterizing homogenous subgroups using data driven multivariate methods. Our results could guide in determining subgroups of VPT born adolescents at the risk of developing behavioral issues as they grow-up.

AB - Here we apply Bi-clustered Independent Component Analysis (B-ICA), a data driven two-dimensional clustering algorithm, on three-dimensional T1-weighted magnetic resonance images of 126 adolescents born very preterm (VPT; < 33 weeks of gestation; mean age=15.29 years; standard deviation=0.58). Two components of interest covering regions of insula and hippocampus showing persisting structural alterations following very preterm birth were chosen, based on previous literature. Corresponding component loadings were sorted using the positive or negative method as suggested by the N-way bi-clustering (n-BIC) algorithm. The association between component loadings and participants' total scores on the Rutter Parents Scale (RPS), a scale measuring emotional and conduct difficulties, was studied in three data- driven subgroups. Loadings of subgroup Sinter (n=32), weighted on both insula and hippocampus imaging components, correlated with RPS Total scores (r=-0.458; p=0.008). Subgroup S1 (n=29), heavily weighted on the insula component, did not show any association between regional brain volume and behavioral outcome. However, for the same S1 subgroup, loadings on the hippocampal component correlated with RPS Total scores (r =-0.61; p=3.43e-4). No significant associations between regional brain volume and behavioral outcome were observed for subgroup S2 (n=34). These results suggest that distinct subgroups of VPT adolescents with similarly increased emotional and conduct problems may have differential underlying brain mechanisms implicating different parts of large-scale emotional and cognitive systems. This study enables interpretation of the neurodevelopmental sequelae in VPT by characterizing homogenous subgroups using data driven multivariate methods. Our results could guide in determining subgroups of VPT born adolescents at the risk of developing behavioral issues as they grow-up.

KW - Adolescents born very preterm

KW - Biclustering

KW - Hippocampus

KW - Insula

KW - Rutter Parents Scale

KW - Structural magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=85187330815&partnerID=8YFLogxK

U2 - 10.1109/INDICON59947.2023.10440727

DO - 10.1109/INDICON59947.2023.10440727

M3 - Paper

AN - SCOPUS:85187330815

SP - 225

EP - 227

T2 - 20th IEEE India Council International Conference, INDICON 2023

Y2 - 14 December 2023 through 17 December 2023

ER -