Ige-mediated fish allergy in children

Betul Buyuktiryaki; Marzio Masini; Francesca Mori; Simona Barni; Giulia Liccioli; Lucrezia Sarti; Lorenzo Lodi; Mattia Giovannini; George du Toit; Andreas Ludwig Lopata; Maria Andreina Marques-Mejias

doi:10.3390/medicina57010076

Ige-mediated fish allergy in children

Betul Buyuktiryaki, Marzio Masini, Francesca Mori, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Lorenzo Lodi, Mattia Giovannini^*, George du Toit, Andreas Ludwig Lopata, Maria Andreina Marques-Mejias

^*Corresponding author for this work

Women & Children's Health

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.

Original language	English
Article number	76
Pages (from-to)	1-22
Number of pages	22
Journal	Medicina (Lithuania)
Volume	57
Issue number	1
DOIs	https://doi.org/10.3390/medicina57010076
Publication status	Published - Jan 2021

Keywords

Allergen
Basophil activation test
Component resolved diagnosis
Fish allergy
Immunoglobulin E
Management
Oral food challenge
Paediatrics
Parvalbumin
Skin prick test

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10.3390/medicina57010076

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title = "Ige-mediated fish allergy in children",

abstract = "Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.",

keywords = "Allergen, Basophil activation test, Component resolved diagnosis, Fish allergy, Immunoglobulin E, Management, Oral food challenge, Paediatrics, Parvalbumin, Skin prick test",

author = "Betul Buyuktiryaki and Marzio Masini and Francesca Mori and Simona Barni and Giulia Liccioli and Lucrezia Sarti and Lorenzo Lodi and Mattia Giovannini and {du Toit}, George and Lopata, {Andreas Ludwig} and Marques-Mejias, {Maria Andreina}",

year = "2021",

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doi = "10.3390/medicina57010076",

language = "English",

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AU - Buyuktiryaki, Betul

AU - Masini, Marzio

AU - Mori, Francesca

AU - Barni, Simona

AU - Liccioli, Giulia

AU - Sarti, Lucrezia

AU - Lodi, Lorenzo

AU - Giovannini, Mattia

AU - du Toit, George

AU - Lopata, Andreas Ludwig

AU - Marques-Mejias, Maria Andreina

PY - 2021/1

Y1 - 2021/1

N2 - Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.

AB - Fish allergy constitutes a severe problem worldwide. Its prevalence has been calculated as high as 7% in paediatric populations, and in many cases, it persists into adulthood with life-threatening signs and symptoms. The following review focuses on the epidemiology of Immunoglobulin E (IgE)-mediated fish allergy, its pathogenesis, clinical manifestations, and a thorough approach to diagnosis and management in the paediatric population. The traditional approach for managing fish allergy is avoidance and rescue medication for accidental exposures. Food avoidance poses many obstacles and is not easily maintained. In the specific case of fish, food is also not the only source of allergens; aerosolisation of fish proteins when cooking is a common source of highly allergenic parvalbumin, and elimination diets cannot prevent these contacts. Novel management approaches based on immunomodulation are a promising strategy for the future of these patients.

KW - Allergen

KW - Basophil activation test

KW - Component resolved diagnosis

KW - Fish allergy

KW - Immunoglobulin E

KW - Management

KW - Oral food challenge

KW - Paediatrics

KW - Parvalbumin

KW - Skin prick test

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DO - 10.3390/medicina57010076

M3 - Review article

AN - SCOPUS:85099651095

SN - 1010-660X

VL - 57

SP - 1

EP - 22

JO - Medicina (Lithuania)

JF - Medicina (Lithuania)

IS - 1

M1 - 76

ER -

Ige-mediated fish allergy in children

Abstract

Keywords

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