IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease

Ushani Srenathan; Kathryn Steel; Leonie S. Taams

doi:10.1016/j.imlet.2016.05.001

IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease

Ushani Srenathan, Kathryn Steel, Leonie S. Taams

Peter Gorer Department of Immunobiology

Research output: Contribution to journal › Literature review › peer-review

117 Citations (Scopus)

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Abstract

The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+ T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease.

Original language	English
Pages (from-to)	20-26
Journal	Immunology Letters
Volume	178
Early online date	9 May 2016
DOIs	https://doi.org/10.1016/j.imlet.2016.05.001
Publication status	Published - Oct 2016

Keywords

CD8+
IL-17
Tc17
inflammation
disease

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title = "IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease",

abstract = "The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+ T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease.",

keywords = "CD8+, IL-17, Tc17, inflammation, disease",

author = "Ushani Srenathan and Kathryn Steel and Taams, {Leonie S.}",

year = "2016",

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language = "English",

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journal = "Immunology Letters",

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TY - JOUR

T1 - IL-17+ CD8+ T cells

T2 - differentiation, phenotype and role in inflammatory disease

AU - Srenathan, Ushani

AU - Steel, Kathryn

AU - Taams, Leonie S.

PY - 2016/10

Y1 - 2016/10

N2 - The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+ T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease.

AB - The pro-inflammatory cytokine interleukin-17A (IL-17) has been the subject of research by many groups worldwide. IL-17 expression is often associated with a specific subset of CD4+ T cells (the so-called Th17 cells); however various other immune cell subsets can also synthesise and express IL-17, including CD8+ T cells. Here we review recent data regarding the presence of IL-17+ CD8+ T cells (also known as Tc17 cells) in human inflammatory disease, discuss current knowledge regarding the culture conditions required for the differentiation of these cells in humans and mice, and describe key phenotypic and functional features. Collectively, this information may shed light on the potential pathogenic role that IL-17+ CD8+ T cells may play in human inflammatory disease.

KW - CD8+

KW - IL-17

KW - Tc17

KW - inflammation

KW - disease

U2 - 10.1016/j.imlet.2016.05.001

DO - 10.1016/j.imlet.2016.05.001

M3 - Literature review

SN - 0165-2478

VL - 178

SP - 20

EP - 26

JO - Immunology Letters

JF - Immunology Letters

ER -

IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease

Abstract

Keywords

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