Image Data Analysis for Quantifying Scar Transmurality in MRI phantoms for Cardiac Resynchronisation Therapy

TY - JOUR

T1 - Image Data Analysis for Quantifying Scar Transmurality in MRI phantoms for Cardiac Resynchronisation Therapy

AU - Karim, Rashed

AU - Panayiotou, Maria

AU - Chowdhury, Onik

AU - Housden, R James

AU - Hummady, Sana

AU - Toth, Daniel

AU - Kurzendorfer, Tanja

AU - Mountney, Peter

AU - Rhode, Kawal

PY - 2018/7

Y1 - 2018/7

N2 - The use of implantable cardiac devices has increased in the last 30 years. Cardiac resynchronisation therapy (CRT) is a procedure which involves implanting a coin sized pacemaker for reversing heart failure. The pacemaker electrode leads are implanted into cardiac myocardial tissue. The optimal site for implantation is highly patient-specific. Most implanters use empirical placement of the lead. One region identified to have a poor response rate are myocardial tissue with transmural scar. Studies that precisely measure transmurality of scar tissue in the left ventricle (LV) are few. Most studies lack proper validation of their transmurality measurement technique. This study presents an image analysis technique for computing scar transmurality from late-gadolinium enhancement MRI. The technique is validated using phantoms under a CRT image guidance system. The study concludes that scar transmurality can be accurately measured in certain situations and validation with phantoms is important.

AB - The use of implantable cardiac devices has increased in the last 30 years. Cardiac resynchronisation therapy (CRT) is a procedure which involves implanting a coin sized pacemaker for reversing heart failure. The pacemaker electrode leads are implanted into cardiac myocardial tissue. The optimal site for implantation is highly patient-specific. Most implanters use empirical placement of the lead. One region identified to have a poor response rate are myocardial tissue with transmural scar. Studies that precisely measure transmurality of scar tissue in the left ventricle (LV) are few. Most studies lack proper validation of their transmurality measurement technique. This study presents an image analysis technique for computing scar transmurality from late-gadolinium enhancement MRI. The technique is validated using phantoms under a CRT image guidance system. The study concludes that scar transmurality can be accurately measured in certain situations and validation with phantoms is important.

U2 - 10.1109/EMBC.2018.8512448

DO - 10.1109/EMBC.2018.8512448

M3 - Article

C2 - 30440584

SN - 1557-170X

VL - 2018

SP - 1111

EP - 1114

JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ER -