Imaging anisotropic and viscous properties of breast tissue by magnetic resonance-elastography

R Sinkus, M Tanter, S Catheline, J Lorenzen, C Kuhl, E Sondermann, M Fink

Research output: Contribution to journalArticlepeer-review

318 Citations (Scopus)

Abstract

MR-elastography is a new technique for assessing the viscoelastic properties of tissue. One current focus of elastography is the provision of new physical parameters for improving the specificity in breast cancer diagnosis. This analysis describes a technique to extend the reconstruction to anisotropic elastic properties in terms of a so-called transversely isotropic model. Viscosity is treated as being isotropic. The particular model chosen for the anisotropy is appealing because it is capable of describing elastic shear anisotropy of parallel fibers. The dependence of the reconstruction on the particular choice of Poisson's ratio is eliminated by extracting the compressional displacement contribution using the Helmholtz-Hodge decomposition. Results are presented for simulations, a polyvinyl alcohol breast phantom, excised beef muscle, and measurements in two patients with breast lesions (invasive ductal carcinoma and fibroadenoma). The results show enhanced anisotropic and viscous properties inside the lesions and an indication for preferred fiber orientation.

Original languageEnglish
Pages (from-to)372-387
Number of pages16
JournalMagnetic Resonance in Medicine
Volume53
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Algorithms
  • Anisotropy
  • Breast
  • Breast Neoplasms
  • Computer Simulation
  • Elasticity
  • Humans
  • Image Interpretation, Computer-Assisted
  • Magnetic Resonance Imaging
  • Models, Biological
  • Phantoms, Imaging
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Viscosity

Fingerprint

Dive into the research topics of 'Imaging anisotropic and viscous properties of breast tissue by magnetic resonance-elastography'. Together they form a unique fingerprint.

Cite this