Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist

Graham Searle, John D Beaver, Robert A Comley, Massimo Bani, Andri Tziortzi, Mark Slifstein, Manolo Mugnaini, Cristiana Griffante, Alan A Wilson, Emilio Merlo-Pich, Sylvain Houle, Roger Gunn, Eugenii A Rabiner, Marc Laruelle

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)

Abstract

Dopamine D(3) receptors are involved in the pathophysiology of several neuropsychiatric conditions. [(11)C]-(+)-PHNO is a radiolabeled D(2) and D(3) agonist, suitable for imaging the agonist binding sites (denoted D(2HIGH) and D(3)) of these receptors with positron emission tomography (PET). PET studies in nonhuman primates documented that, in vivo, [(11)C]-(+)-PHNO displays a relative selectivity for D(3) compared with D(2HIGH) receptor sites and that the [(11)C]-(+)-PHNO signal is enriched in D(3) contribution compared with conventional ligands such as [(11)C] raclopride.
Original languageEnglish
Pages (from-to)392-9
Number of pages8
JournalBiological psychiatry
Volume68
Issue number4
DOIs
Publication statusPublished - 2010

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