Imaging Methods: Magnetic Resonance Imaging

Katharine E. Thomas; Anastasia Fotaki; René M. Botnar; Vanessa M. Ferreira

doi:10.1161/CIRCIMAGING.122.014068

Imaging Methods: Magnetic Resonance Imaging

Katharine E. Thomas, Anastasia Fotaki, René M. Botnar, Vanessa M. Ferreira^*

^*Corresponding author for this work

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Myocardial inflammation occurs following activation of the cardiac immune system, producing characteristic changes in the myocardial tissue. Cardiovascular magnetic resonance is the non-invasive imaging gold standard for myocardial tissue characterization, and is able to detect image signal changes that may occur resulting from inflammation, including edema, hyperemia, capillary leak, necrosis, and fibrosis. Conventional cardiovascular magnetic resonance for the detection of myocardial inflammation and its sequela include T2-weighted imaging, parametric T1- and T2-mapping, and gadolinium-based contrast-enhanced imaging. Emerging techniques seek to image several parameters simultaneously for myocardial tissue characterization, and to depict subtle immune-mediated changes, such as immune cell activity in the myocardium and cardiac cell metabolism. This review article outlines the underlying principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.

Original language	English
Pages (from-to)	E014068
Journal	Circulation: Cardiovascular Imaging
Volume	16
Issue number	1
DOIs	https://doi.org/10.1161/CIRCIMAGING.122.014068
Publication status	Published - 1 Jan 2023

Keywords

cardiac imaging techniques
immune system
inflammation
magnetic resonance imaging

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10.1161/CIRCIMAGING.122.014068

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title = "Imaging Methods: Magnetic Resonance Imaging",

abstract = "Myocardial inflammation occurs following activation of the cardiac immune system, producing characteristic changes in the myocardial tissue. Cardiovascular magnetic resonance is the non-invasive imaging gold standard for myocardial tissue characterization, and is able to detect image signal changes that may occur resulting from inflammation, including edema, hyperemia, capillary leak, necrosis, and fibrosis. Conventional cardiovascular magnetic resonance for the detection of myocardial inflammation and its sequela include T2-weighted imaging, parametric T1- and T2-mapping, and gadolinium-based contrast-enhanced imaging. Emerging techniques seek to image several parameters simultaneously for myocardial tissue characterization, and to depict subtle immune-mediated changes, such as immune cell activity in the myocardium and cardiac cell metabolism. This review article outlines the underlying principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.",

keywords = "cardiac imaging techniques, immune system, inflammation, magnetic resonance imaging",

author = "Thomas, {Katharine E.} and Anastasia Fotaki and Botnar, {Ren{\'e} M.} and Ferreira, {Vanessa M.}",

note = "Funding Information: Dr Ferreira acknowledges support from the British Heart Foundation (BHF) (CH/16/1/32013), the Oxford BHF Centre of Research Excellence, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre at The Oxford University Hospitals NHS Foundation Trust. Dr Thomas acknowledges British Heart Foundation Clinical Research Training Fellowship (FS/CRTF/21/24268). Drs Botnar and Fotaki acknowledge financial support from the British Heart Foundation PG/18/59/33955 and RG/20/1/34802, Engineering and Physical Sciences Research Council EP/P001009, EP/P032311/1, EP/P007619, Wellcome EPSRC (Engineering and Physical Sciences Research Council) Centre for Medical Engineering (NS/A000049/1), Millennium Institute for Intelligent Healthcare Engineering ICN2021_004 and the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy{\textquoteright}s and St. Thomas{\textquoteright} NHS Foundation Trust. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR, or the Department of Health. Funding Information: Dr Ferreira acknowledges support from the British Heart Foundation (BHF) (CH/16/1/32013), the Oxford BHF Centre of Research Excellence, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre at The Oxford University Hospitals NHS Foundation Trust. Dr Thomas acknowledges British Heart Foundation Clinical Research Training Fellowship (FS/CRTF/21/24268). Drs Botnar and Fotaki acknowledge financial support from the British Heart Foundation PG/18/59/33955 and RG/20/1/34802, Engineering and Physical Sciences Research Council EP/P001009, EP/ P032311/1, EP/P007619, Wellcome EPSRC (Engineering and Physical Sciences Research Council) Centre for Medical Engineering (NS/A000049/1), Millennium Institute for Intelligent Healthcare Engineering ICN2021-004 and the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's and St. Thomas' NHS Foundation Trust. The views expressed are those of the authors and not necessarily those of the National Health Service (NHS), the NIHR, or the Department of Health. Publisher Copyright: {\textcopyright} 2022 American Heart Association, Inc.",

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doi = "10.1161/CIRCIMAGING.122.014068",

language = "English",

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AU - Fotaki, Anastasia

AU - Botnar, René M.

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N2 - Myocardial inflammation occurs following activation of the cardiac immune system, producing characteristic changes in the myocardial tissue. Cardiovascular magnetic resonance is the non-invasive imaging gold standard for myocardial tissue characterization, and is able to detect image signal changes that may occur resulting from inflammation, including edema, hyperemia, capillary leak, necrosis, and fibrosis. Conventional cardiovascular magnetic resonance for the detection of myocardial inflammation and its sequela include T2-weighted imaging, parametric T1- and T2-mapping, and gadolinium-based contrast-enhanced imaging. Emerging techniques seek to image several parameters simultaneously for myocardial tissue characterization, and to depict subtle immune-mediated changes, such as immune cell activity in the myocardium and cardiac cell metabolism. This review article outlines the underlying principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.

AB - Myocardial inflammation occurs following activation of the cardiac immune system, producing characteristic changes in the myocardial tissue. Cardiovascular magnetic resonance is the non-invasive imaging gold standard for myocardial tissue characterization, and is able to detect image signal changes that may occur resulting from inflammation, including edema, hyperemia, capillary leak, necrosis, and fibrosis. Conventional cardiovascular magnetic resonance for the detection of myocardial inflammation and its sequela include T2-weighted imaging, parametric T1- and T2-mapping, and gadolinium-based contrast-enhanced imaging. Emerging techniques seek to image several parameters simultaneously for myocardial tissue characterization, and to depict subtle immune-mediated changes, such as immune cell activity in the myocardium and cardiac cell metabolism. This review article outlines the underlying principles of current and emerging cardiovascular magnetic resonance methods for imaging myocardial inflammation.

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Imaging Methods: Magnetic Resonance Imaging

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