TY - JOUR
T1 - Imaging the Tumor Antioxidant Response with [18F]FSPG PET
AU - Vilhelmsson Timmermand, Oskar
AU - Witney, Timothy H
N1 - Publisher Copyright:
© The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2023/11/27
Y1 - 2023/11/27
N2 - (4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.
AB - (4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.
KW - Humans
KW - Antioxidants
KW - Cystine
KW - Positron-Emission Tomography/methods
KW - Neoplasms/diagnostic imaging
KW - Glutamic Acid
UR - http://www.scopus.com/inward/record.url?scp=85177728820&partnerID=8YFLogxK
U2 - 10.1007/978-1-0716-3499-8_14
DO - 10.1007/978-1-0716-3499-8_14
M3 - Article
C2 - 38006500
SN - 1940-6029
VL - 2729
SP - 233
EP - 249
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
ER -