Imaging with radiolabelled bisphosphonates

TY - JOUR

T1 - Imaging with radiolabelled bisphosphonates

AU - Cook, Gary J.R.

PY - 2020/8

Y1 - 2020/8

N2 - Radiolabeled bisphosphonates were developed in the 1970s for scintigraphic functional imaging of the skeleton in benign and malignant disease. Tracers such as 99mTc-methylene diphosphonate, that map focal or global changes in mineralization in the skeleton qualitatively and quantitatively, have been the backbone of nuclear medicine imaging for decades. While competing technologies are evolving, new indications and improvements in scanner hardware, in particular hybrid imaging (e.g. single photon emission computed tomography combined with computed tomography), have allowed improved diagnostic accuracy and a continued role for radiolabeled bisphosphonate imaging in current practice.

AB - Radiolabeled bisphosphonates were developed in the 1970s for scintigraphic functional imaging of the skeleton in benign and malignant disease. Tracers such as 99mTc-methylene diphosphonate, that map focal or global changes in mineralization in the skeleton qualitatively and quantitatively, have been the backbone of nuclear medicine imaging for decades. While competing technologies are evolving, new indications and improvements in scanner hardware, in particular hybrid imaging (e.g. single photon emission computed tomography combined with computed tomography), have allowed improved diagnostic accuracy and a continued role for radiolabeled bisphosphonate imaging in current practice.

KW - 99m-technetium

KW - Bisphosphonates

KW - Diphosphonates

KW - Gamma camera

KW - Imaging

KW - Single photon emission computed tomography

UR - http://www.scopus.com/inward/record.url?scp=85085094274&partnerID=8YFLogxK

U2 - 10.1016/j.bone.2020.115372

DO - 10.1016/j.bone.2020.115372

M3 - Article

C2 - 32353566

AN - SCOPUS:85085094274

SN - 8756-3282

VL - 137

JO - Bone

JF - Bone

M1 - 115372

ER -