Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection

Petra Mlcochova; Luis Apolonia; Silvia F Kluge; Aishwarya Sridharan; Frank Kirchhoff; Michael H Malim; Daniel Sauter; Ravindra K Gupta

doi:10.1016/j.virol.2015.03.015

Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection

Petra Mlcochova, Luis Apolonia, Silvia F Kluge, Aishwarya Sridharan, Frank Kirchhoff, Michael H Malim, Daniel Sauter, Ravindra K Gupta

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection.

Original language	English
Pages (from-to)	72-78
Number of pages	7
Journal	Virology
Volume	482
DOIs	https://doi.org/10.1016/j.virol.2015.03.015
Publication status	Published - 30 Mar 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.virol.2015.03.015

Cite this

@article{877855820e7d46788e79c090bedd7e52,

title = "Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection",

abstract = "Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection.",

author = "Petra Mlcochova and Luis Apolonia and Kluge, {Silvia F} and Aishwarya Sridharan and Frank Kirchhoff and Malim, {Michael H} and Daniel Sauter and Gupta, {Ravindra K}",

year = "2015",

month = mar,

day = "30",

doi = "10.1016/j.virol.2015.03.015",

language = "English",

volume = "482",

pages = "72--78",

journal = "Virology",

issn = "0042-6822",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection

AU - Mlcochova, Petra

AU - Apolonia, Luis

AU - Kluge, Silvia F

AU - Sridharan, Aishwarya

AU - Kirchhoff, Frank

AU - Malim, Michael H

AU - Sauter, Daniel

AU - Gupta, Ravindra K

PY - 2015/3/30

Y1 - 2015/3/30

N2 - Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection.

AB - Heterosexual HIV-1 transmission has been identified as a genetic bottleneck and a single transmitted/founder (T/F) variant with reduced sensitivity to type I interferon initiates productive infection in most cases. We hypothesized that particularly active accessory protein(s) may confer T/F viruses with a selective advantage in establishing HIV infection. Thus, we tested vpu, vif and nef alleles from six T/F and six chronic (CC) viruses in assays for 9 immune evasion activities involving the counteraction of interferon-stimulated genes and modulation of ligands known to activate innate immune cells. All functions were highly conserved with no significant differences between T/F and CC viruses, suggesting that these accessory protein functions are important throughout the course of infection.

U2 - 10.1016/j.virol.2015.03.015

DO - 10.1016/j.virol.2015.03.015

M3 - Article

C2 - 25827531

SN - 0042-6822

VL - 482

SP - 72

EP - 78

JO - Virology

JF - Virology

ER -

Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this