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Immune mechanisms of food allergy and its prevention by early intervention

Research output: Contribution to journalArticle

Victor Turcanu ; Helen A Brough ; George Du Toit ; Ru-Xin Foong ; Tom Marrs ; Alexandra F Santos ; Gideon Lack

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalCurrent Opinion in Immunology
Volume48
Early online date9 Sep 2017
DOIs
StateE-pub ahead of print - 9 Sep 2017

King's Authors

Abstract

The environmental factors driving the increase in food allergies are unclear and possibly involve dual exposure to allergens, microbiome-driven effects or other mechanisms. Until they can be better understood, early intervention aiming at establishing oral tolerance provides an effective way to decrease the window-of-risk when children may develop allergic sensitisation to foods due to the absence of a protective immune response. Thus, the recent LEAP (Learning Early About Peanut allergy) and LEAP-On studies achieved a high level of peanut allergy prevention by early introduction of peanuts in the infants diet and conveyed more information regarding the evolution of IgE and IgG4 antibody responses to food antigens over time.

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