Immune responses in perinatal brain injury

TY - JOUR

T1 - Immune responses in perinatal brain injury

AU - Hagberg, Erik Gustaf Henrik

PY - 2016/11/16

Y1 - 2016/11/16

N2 - The perinatal period has often been described as immune deficient. However, it has become clear thatimmune responses in the neonate following exposure to microbes or as a result of tissue injury maybe substantial and play a role in perinatal brain injury. In this article we will review the immune cell compositionunder normal physiological conditions in the perinatal period, both in the human and rodent.We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immuneactivation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxicischemicbrain injury.

AB - The perinatal period has often been described as immune deficient. However, it has become clear thatimmune responses in the neonate following exposure to microbes or as a result of tissue injury maybe substantial and play a role in perinatal brain injury. In this article we will review the immune cell compositionunder normal physiological conditions in the perinatal period, both in the human and rodent.We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immuneactivation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxicischemicbrain injury.

U2 - 10.1016/j.bbi.2016.10.022

DO - 10.1016/j.bbi.2016.10.022

M3 - Article

SN - 0889-1591

SP - 1

EP - 14

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

ER -