Immune responses in perinatal brain injury

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34 Citations (Scopus)


The perinatal period has often been described as immune deficient. However, it has become clear that
immune responses in the neonate following exposure to microbes or as a result of tissue injury may
be substantial and play a role in perinatal brain injury. In this article we will review the immune cell composition
under normal physiological conditions in the perinatal period, both in the human and rodent.
We will summarize evidence of the inflammatory responses to stimuli and discuss how neonatal immune
activation, both in the central nervous system and in the periphery, may contribute to perinatal hypoxicischemic
brain injury.
Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalBrain, Behavior, and Immunity
Early online date16 Nov 2016
Publication statusE-pub ahead of print - 16 Nov 2016


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