Immunoregulation in the tissues by gamma delta T cells

TY - JOUR

T1 - Immunoregulation in the tissues by gamma delta T cells

AU - Hayday, A

AU - Tigelaar, R

PY - 2003/3

Y1 - 2003/3

N2 - For a T-cell subset to be classified as immunoregulatory, it might reasonably be predicted that in its absence, animals would experience pathological immune dysregulation. Moreover, reconstitution of the subset should restore normal immune regulation. So far, these criteria have been satisfied by only a few of the candidate regulatory T-cell subsets, but among them is the intraepithelial gammadelta T-cell receptor (TCR)(+) subset of mouse skin. In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells.

AB - For a T-cell subset to be classified as immunoregulatory, it might reasonably be predicted that in its absence, animals would experience pathological immune dysregulation. Moreover, reconstitution of the subset should restore normal immune regulation. So far, these criteria have been satisfied by only a few of the candidate regulatory T-cell subsets, but among them is the intraepithelial gammadelta T-cell receptor (TCR)(+) subset of mouse skin. In this article, we look at immunoregulatory gammadelta T cells, and the growing evidence for tissue-associated immunoregulation mediated by both gammadelta T cells and alphabeta T cells.

U2 - 10.1038/nri1030

DO - 10.1038/nri1030

M3 - Literature review

VL - 3

SP - 233

EP - 242

JO - NATURE REVIEWS IMMUNOLOGY

JF - NATURE REVIEWS IMMUNOLOGY

IS - 3

ER -