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Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis

Research output: Contribution to journalArticlepeer-review

Claudia Gulea, Rosita Zakeri, Constantinos Kallis, Jennifer K. Quint

Original languageEnglish
Article numbere059122
Pages (from-to)e059122
JournalBMJ Open
Issue number6
Published30 Jun 2022

Bibliographical note

Funding Information: CG is funded by a NHLI PhD studentship. Grant number: N/A. Publisher Copyright: © Author(s) (or their employer(s)) 2022.

King's Authors


OBJECTIVE: To evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF). SETTING: Data were obtained from patients enrolled in the National Heart Failure Audit. PARTICIPANTS: 217 329 patients hospitalised for HF in England-Wales between March 2012 and 2018. OUTCOMES: In-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression. RESULTS: Patients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). In patients who survived to discharge, referral to HF follow-up services differed between groups: patients with COPD-HF had reduced odds of cardiology follow-up (ORadj, 95% CI 0.79, 0.77 to 0.81), while cardiology referral odds for asthma-HF were similar to HF-alone. Overall, proportions of HF medication prescriptions at discharge were low for both COPD-HF and asthma-HF groups, particularly prescriptions for beta-blockers. CONCLUSIONS: In this nationwide analysis, we showed that COPD and asthma significantly impact the clinical course in patients hospitalised for HF. COPD is associated with higher in-patient mortality and lower cardiology referral odds, while COPD and asthma are both associated with lower use of prognostic HF therapies on discharge. These data highlight therapeutic gaps and a need for better integration of cardiopulmonary services to improve healthcare provision for patients with HF and coexisting respiratory disease.

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