Impact of Different Childhood Adversities on 1-year Outcomes of Psychotic Disorder in the Genetics and Psychosis study

Antonella Trotta; Robin M Murray; Anthony S David; Anna Kolliakou; Jennifer O'Connor; Marta Di Forti; Paola Dazzan; Valeria Mondelli; Craig Morgan; Helen L Fisher

doi:10.1093/schbul/sbv131

Impact of Different Childhood Adversities on 1-year Outcomes of Psychotic Disorder in the Genetics and Psychosis study

Antonella Trotta, Robin M Murray, Anthony S David, Anna Kolliakou, Jennifer O'Connor, Marta Di Forti, Paola Dazzan, Valeria Mondelli, Craig Morgan, Helen L Fisher

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Abstract

While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-presentation psychosis patients. Exposure to childhood adversity prior to 17 years of age was assessed using the Childhood Experience of Care and Abuse Questionnaire. Data on illness course, symptom remission, length of psychiatric hospitalization, compliance with medication, employment, and relationship status were extracted from clinical records for the year following first contact with mental health services for psychosis. Seventy-one percent of patients reported exposure to at least 1 type of childhood adversity (physical abuse, sexual abuse, parental separation, parental death, disrupted family arrangements, or being taken into care). No robust associations were found between childhood adversity and illness course or remission. However, childhood physical abuse was associated with almost 3-fold increased odds of not being in a relationship at 1-year follow-up compared to patients who did not report such adverse experiences. There was also evidence of a significant association between parental separation in childhood and longer admissions to psychiatric wards during 1-year follow-up and 2-fold increased odds of noncompliance with medication compared to those not separated from their parents. Therefore, our findings suggest that there may be some specificity in the impact of childhood adversity on service use and social functioning among psychosis patients over the first year following presentation to mental health services.

Original language	English
Pages (from-to)	464-475
Journal	Schizophrenia Bulletin
Volume	42
Issue number	2
Early online date	15 Sept 2015
DOIs	https://doi.org/10.1093/schbul/sbv131
Publication status	Published - Mar 2016

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Schizophr Bull-2016-Trotta-464-75Final published version, 340 KBLicence: CC BY

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title = "Impact of Different Childhood Adversities on 1-year Outcomes of Psychotic Disorder in the Genetics and Psychosis study",

abstract = "While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-presentation psychosis patients. Exposure to childhood adversity prior to 17 years of age was assessed using the Childhood Experience of Care and Abuse Questionnaire. Data on illness course, symptom remission, length of psychiatric hospitalization, compliance with medication, employment, and relationship status were extracted from clinical records for the year following first contact with mental health services for psychosis. Seventy-one percent of patients reported exposure to at least 1 type of childhood adversity (physical abuse, sexual abuse, parental separation, parental death, disrupted family arrangements, or being taken into care). No robust associations were found between childhood adversity and illness course or remission. However, childhood physical abuse was associated with almost 3-fold increased odds of not being in a relationship at 1-year follow-up compared to patients who did not report such adverse experiences. There was also evidence of a significant association between parental separation in childhood and longer admissions to psychiatric wards during 1-year follow-up and 2-fold increased odds of noncompliance with medication compared to those not separated from their parents. Therefore, our findings suggest that there may be some specificity in the impact of childhood adversity on service use and social functioning among psychosis patients over the first year following presentation to mental health services.",

author = "Antonella Trotta and Murray, {Robin M} and David, {Anthony S} and Anna Kolliakou and Jennifer O'Connor and {Di Forti}, Marta and Paola Dazzan and Valeria Mondelli and Craig Morgan and Fisher, {Helen L}",

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AU - Murray, Robin M

AU - David, Anthony S

AU - Kolliakou, Anna

AU - O'Connor, Jennifer

AU - Di Forti, Marta

AU - Dazzan, Paola

AU - Mondelli, Valeria

AU - Morgan, Craig

AU - Fisher, Helen L

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Impact of Different Childhood Adversities on 1-year Outcomes of Psychotic Disorder in the Genetics and Psychosis study

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