Abstract
mpact of ethnicity and diabetic retinopathy on faster progression of kidney function loss in an ethnically diverse cohort of people with type 2 diabetes
T Alobaid1, M O'Connell2, J Karalliedde3, S Ayis4
1Population Health Sciences, King's College London, London, UK; 2Population Health Sciences, King's College London, London, UK; 3School of Cardiovascular and Metabolic Medicine Sciences, King's College London, London, UK; 4Population Health Sciences, King's College London, London, UK
Aim: This study aimed to explore estimated glomerular filtration rate (eGFR) trajectories in an ethnically diverse cohort with type 2 diabetes, and to identify the risk factors associated with faster decline in kidney function.
Methods: We evaluated a cohort of 14,572 people (females 50.44%) with type 2 diabetes and baseline eGFR ≥45 mL/min/1.73 m2 attending two hospitals in London between 2004 and 2018. Group-based trajectory models were used to assess eGFR progression patterns. Multinomial logistic regression was applied to identify risk factors for progression to chronic kidney disease (CKD) stage 5. The prevalence of baseline diabetic retinopathy (DR) in people with faster progression of CKD was also explored. Ethnicity was self-reported.
Results: Of the 14,572 participants, 17.4% (n = 2531) exhibited the fastest eGFR decline (annual eGFR – 1.92 to–2.78 mL/min/1.73 m2/year). In this group, 50.5% were White, 32.4% Black and 9.4% Asian. Progression to stage 5 CKD occurred in 14.5% of this subgroup. After adjusting for traditional risk factors, Black ethnicity had a 1.64-fold increased risk (95% CI: 1.22–2.21, p < 0.05) and Asian ethnicity had 2.39-fold increased risk (95% CI: 1.57–3.64, p < 0.05) of progressing to stage 5 CKD compared with White ethnicity.
In those with CKD progression, the prevalence of DR varied with White (44.5%), Black (54.3%), Asian (59.4%) and mixed (56.4%).
Conclusion: We identified four distinct eGFR progression patterns in people with type 2 diabetes, with non-White ethnicities showing a higher prevalence of faster progression to CKD stage 5. In people with fast progression, DR prevalence was lower among the White compared with others.
T Alobaid1, M O'Connell2, J Karalliedde3, S Ayis4
1Population Health Sciences, King's College London, London, UK; 2Population Health Sciences, King's College London, London, UK; 3School of Cardiovascular and Metabolic Medicine Sciences, King's College London, London, UK; 4Population Health Sciences, King's College London, London, UK
Aim: This study aimed to explore estimated glomerular filtration rate (eGFR) trajectories in an ethnically diverse cohort with type 2 diabetes, and to identify the risk factors associated with faster decline in kidney function.
Methods: We evaluated a cohort of 14,572 people (females 50.44%) with type 2 diabetes and baseline eGFR ≥45 mL/min/1.73 m2 attending two hospitals in London between 2004 and 2018. Group-based trajectory models were used to assess eGFR progression patterns. Multinomial logistic regression was applied to identify risk factors for progression to chronic kidney disease (CKD) stage 5. The prevalence of baseline diabetic retinopathy (DR) in people with faster progression of CKD was also explored. Ethnicity was self-reported.
Results: Of the 14,572 participants, 17.4% (n = 2531) exhibited the fastest eGFR decline (annual eGFR – 1.92 to–2.78 mL/min/1.73 m2/year). In this group, 50.5% were White, 32.4% Black and 9.4% Asian. Progression to stage 5 CKD occurred in 14.5% of this subgroup. After adjusting for traditional risk factors, Black ethnicity had a 1.64-fold increased risk (95% CI: 1.22–2.21, p < 0.05) and Asian ethnicity had 2.39-fold increased risk (95% CI: 1.57–3.64, p < 0.05) of progressing to stage 5 CKD compared with White ethnicity.
In those with CKD progression, the prevalence of DR varied with White (44.5%), Black (54.3%), Asian (59.4%) and mixed (56.4%).
Conclusion: We identified four distinct eGFR progression patterns in people with type 2 diabetes, with non-White ethnicities showing a higher prevalence of faster progression to CKD stage 5. In people with fast progression, DR prevalence was lower among the White compared with others.
| Original language | English |
|---|---|
| Title of host publication | Journal Of Diabetec Medicine |
| Subtitle of host publication | Supplement: Abstracts of the Diabetes UK Professional Conference 2025, SEC Glasgow, 26–28 February 2025 |
| Publisher | Wiley |
| Pages | e15498 |
| Volume | 42 |
| Edition | S1 |
| DOIs | |
| Publication status | Published - 25 Feb 2025 |
Publication series
| Name | Diabetic medicine : a journal of the British Diabetic Association |
|---|---|
| Publisher | Wiley-Blackwell Publishing Ltd |
| ISSN (Print) | 0742-3071 |
