Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

Daniela Martini, Laura Chiavaroli, Antonio González-Sarrías, Letizia Bresciani, Susana A Palma-Duran, Margherita Dall'Asta, Georgia-Eirini Deligiannidou, Marika Massaro, Egeria Scoditti, Emilie Combet, Viktorija Maksimova, Mireia Urpi-Sarda, Christos A Kontogiorgis, Cristina Andrés-Lacueva, Eileen R Gibney, Daniele Del Rio, Christine Morand, Mar Garcia-Aloy, Ana Rodriguez-Mateos, Pedro Mena

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)
118 Downloads (Pure)

Abstract

Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.

Original languageEnglish
Article number1805
JournalNutrients
Volume11
Issue number8
DOIs
Publication statusPublished - 5 Aug 2019

Keywords

  • Artichoke
  • Caffeoylquinic acids
  • Cardiometabolic health
  • Cereals
  • Coffee
  • Dietary supplements
  • Hydroxycinnamic acids
  • Interindividual variability
  • Polyphenols
  • Potato

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