TY - JOUR
T1 - Impact of MRI markers in subcortical vascular dementia
T2 - a multi-modal analysis in CADASIL
AU - Viswanathan, Anand
AU - Godin, Ophelia
AU - Jouvent, Eric
AU - O'Sullivan, Michael
AU - Gschwendtner, Andreas
AU - Peters, Nils
AU - Duering, Marco
AU - Guichard, Jean-Pierre
AU - Holtmannspötter, Markus
AU - Dufouil, Carole
AU - Pachai, Chahin
AU - Bousser, Marie-Germaine
AU - Dichgans, Martin
AU - Chabriat, Hugues
N1 - Copyright 2008 Elsevier Inc. All rights reserved.
PY - 2010/9
Y1 - 2010/9
N2 - CADASIL is an arteriopathy caused by mutations of the Notch3 gene. White matter hyperintensities (WMH), lacunar lesions (LL), cerebral microhemorrhages (CM), brain atrophy and tissue microstructural changes are detected on MRI. Using an integrated multi-modal approach, we examined the relative impact of lesion burden and location of these MRI markers on cognitive impairment and disability. Multi-modal imaging was performed on 147 patients from a two-center cohort study. Volume of LL, WMH and number of CM was determined. Whole brain mean apparent diffusion coefficient (mean-ADC) and brain parenchymal fraction (BPF) were measured. In multivariate models accounting for lesion burden and location, volume of LL, mean-ADC, and BPF each had an independent influence on global cognitive function and disability. BPF explained the largest portion of the variation in cognitive and disability scores (35-38%). Brain atrophy has the strongest independent influence on clinical impairment in CADASIL when all MRI markers in the disease are considered together. The results suggest that the clinical impact of cerebral tissue loss plays a principal role in this genetic model of subcortical ischemic vascular dementia.
AB - CADASIL is an arteriopathy caused by mutations of the Notch3 gene. White matter hyperintensities (WMH), lacunar lesions (LL), cerebral microhemorrhages (CM), brain atrophy and tissue microstructural changes are detected on MRI. Using an integrated multi-modal approach, we examined the relative impact of lesion burden and location of these MRI markers on cognitive impairment and disability. Multi-modal imaging was performed on 147 patients from a two-center cohort study. Volume of LL, WMH and number of CM was determined. Whole brain mean apparent diffusion coefficient (mean-ADC) and brain parenchymal fraction (BPF) were measured. In multivariate models accounting for lesion burden and location, volume of LL, mean-ADC, and BPF each had an independent influence on global cognitive function and disability. BPF explained the largest portion of the variation in cognitive and disability scores (35-38%). Brain atrophy has the strongest independent influence on clinical impairment in CADASIL when all MRI markers in the disease are considered together. The results suggest that the clinical impact of cerebral tissue loss plays a principal role in this genetic model of subcortical ischemic vascular dementia.
KW - Sensitivity and Specificity
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Reproducibility of Results
KW - Humans
KW - Brain
KW - Multivariate Analysis
KW - France
KW - CADASIL
KW - Image Enhancement
KW - Middle Aged
KW - Germany
KW - Female
KW - Male
U2 - 10.1016/j.neurobiolaging.2008.09.001
DO - 10.1016/j.neurobiolaging.2008.09.001
M3 - Article
C2 - 18926602
SN - 1558-1497
VL - 31
SP - 1629
EP - 1636
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 9
ER -