Impact of peanut consumption in the LEAP Study: Feasibility, growth, and nutrition

Mary Feeney, George Du Toit, Graham Roberts, Peter H. Sayre, Kaitie Lawson, Henry T. Bahnson, Michelle L. Sever, Suzana Radulovic, Marshall Plaut, Gideon Lack

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66 Citations (Scopus)
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Background Early introduction of peanut is an effective strategy to prevent peanut allergy in high-risk infants; however, feasibility and effects on growth and nutritional intake are unknown. Objective We sought to evaluate the feasibility of introducing peanut in infancy and explore effects on growth and nutritional intake up to age 60 months. Methods In the Learning Early About Peanut Allergy trial, 640 atopic infants aged 4 to 11 months were randomly assigned to consume (6 g peanut protein per week) or avoid peanut until age 60 months. Peanut consumption and early feeding practices were assessed by questionnaire. Dietary intake was evaluated with prospective food diaries. Anthropometric measurements were taken at all study visits. Results Peanut was successfully introduced and consumed until 60 months, with median peanut protein intake of 7.5 g/wk (interquartile range, 6.0-9.0 g/wk) in the consumption group compared with 0 g in the avoidance group. Introduction of peanut in breast-feeding infants did not affect the duration of breast-feeding. There were no differences in anthropometric measurements or energy intakes between groups at any visits. Regular peanut consumption led to differences in dietary intakes. Consumers had higher intakes of fat and avoiders had higher carbohydrate intakes; differences were greatest at the upper quartiles of peanut consumption. Protein intakes remained consistent between groups. Conclusions Introduction of peanut proved feasible in infants at high risk of peanut allergy and did not affect the duration of breast-feeding nor impact negatively on growth or nutrition. Energy balance was achieved in both groups through variations in intakes from fat and carbohydrate while protein homeostasis was maintained.
Original languageEnglish
Pages (from-to)1108-1118
Number of pages11
JournalJournal of Allergy and Clinical Immunology
Issue number4
Early online date10 Jun 2016
Publication statusPublished - 1 Oct 2016


  • Food allergy
  • allergy prevention
  • peanut
  • infant feeding
  • breast-feeding
  • nutrition
  • growth
  • prospective food diary
  • protein homeostasis


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