Impact of subjective vs. objective remission status on subjective cognitive impairments in depression

Kyosuke Sawada, Kazunari Yoshida, Chisa Ozawa, Yuya Mizuno, Ellen B. Rubinstein, Takefumi Suzuki, Masaru Mimura, Hiroyuki Uchida

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)
273 Downloads (Pure)

Abstract

Objective The impact of subjective versus objective illness severity on subjective cognitive impairment in patients with depression has not been addressed. Methods This study is a post-hoc analysis of our cross-sectional study in Japanese outpatients with depressive disorder (ICD-10) (Ozawa et al., 2017). The participants received assessments with the Japanese version of the Perceived Deficits Questionnaire (J-PDQ), Quick Inventory of Depressive Symptomatology (QIDS), and Montgomery-Asberg Depression Rating Scale (MADRS). First, multiple regression analysis was conducted to examine the effects of demographic and clinical characteristics, including illness severity and medications (e.g., antidepressants and benzodiazepines), on the PDQ total score. Next, we categorized the participants into 4 groups based on the presence/absence of subjective and objective symptom remission (i.e., QIDS total score of ≤5 and MADRS total score of ≤9, respectively), and compared the differences in PDQ total scores between the QIDS- and MADRS-remitted group and the QIDS-non-remitted but MADRS-remitted group. Results 102 participants were included (45 men; mean±SD age, 50.5±14.7 years). Higher QIDS and MADRS total scores were significantly associated with a greater PDQ total score (both p's
Original languageEnglish
JournalJournal of Affective Disorders
Early online date18 Dec 2018
DOIs
Publication statusE-pub ahead of print - 18 Dec 2018

Keywords

  • Depression
  • Illness severity
  • PDQ
  • Subjective cognitive impairment

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