Impact of subjective vs. objective remission status on subjective cognitive impairments in depression

Kyosuke Sawada; Kazunari Yoshida; Chisa Ozawa; Yuya Mizuno; Ellen B. Rubinstein; Takefumi Suzuki; Masaru Mimura; Hiroyuki Uchida

doi:10.1016/j.jad.2018.12.049

Impact of subjective vs. objective remission status on subjective cognitive impairments in depression

Kyosuke Sawada, Kazunari Yoshida, Chisa Ozawa, Yuya Mizuno, Ellen B. Rubinstein, Takefumi Suzuki, Masaru Mimura, Hiroyuki Uchida

Psychosis Studies

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

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Abstract

Objective The impact of subjective versus objective illness severity on subjective cognitive impairment in patients with depression has not been addressed. Methods This study is a post-hoc analysis of our cross-sectional study in Japanese outpatients with depressive disorder (ICD-10) (Ozawa et al., 2017). The participants received assessments with the Japanese version of the Perceived Deficits Questionnaire (J-PDQ), Quick Inventory of Depressive Symptomatology (QIDS), and Montgomery-Asberg Depression Rating Scale (MADRS). First, multiple regression analysis was conducted to examine the effects of demographic and clinical characteristics, including illness severity and medications (e.g., antidepressants and benzodiazepines), on the PDQ total score. Next, we categorized the participants into 4 groups based on the presence/absence of subjective and objective symptom remission (i.e., QIDS total score of ≤5 and MADRS total score of ≤9, respectively), and compared the differences in PDQ total scores between the QIDS- and MADRS-remitted group and the QIDS-non-remitted but MADRS-remitted group. Results 102 participants were included (45 men; mean±SD age, 50.5±14.7 years). Higher QIDS and MADRS total scores were significantly associated with a greater PDQ total score (both p's

Original language	English
Journal	Journal of Affective Disorders
Early online date	18 Dec 2018
DOIs	https://doi.org/10.1016/j.jad.2018.12.049
Publication status	E-pub ahead of print - 18 Dec 2018

Keywords

Depression
Illness severity
PDQ
Subjective cognitive impairment

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10.1016/j.jad.2018.12.049

Impact of subjective vs. objective_SAWADA_Firstonline18December2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 749 KBLicence: CC BY-NC-ND

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@article{4d544a4bce3048859071407232248cab,

title = "Impact of subjective vs. objective remission status on subjective cognitive impairments in depression",

abstract = "Objective The impact of subjective versus objective illness severity on subjective cognitive impairment in patients with depression has not been addressed. Methods This study is a post-hoc analysis of our cross-sectional study in Japanese outpatients with depressive disorder (ICD-10) (Ozawa et al., 2017). The participants received assessments with the Japanese version of the Perceived Deficits Questionnaire (J-PDQ), Quick Inventory of Depressive Symptomatology (QIDS), and Montgomery-Asberg Depression Rating Scale (MADRS). First, multiple regression analysis was conducted to examine the effects of demographic and clinical characteristics, including illness severity and medications (e.g., antidepressants and benzodiazepines), on the PDQ total score. Next, we categorized the participants into 4 groups based on the presence/absence of subjective and objective symptom remission (i.e., QIDS total score of ≤5 and MADRS total score of ≤9, respectively), and compared the differences in PDQ total scores between the QIDS- and MADRS-remitted group and the QIDS-non-remitted but MADRS-remitted group. Results 102 participants were included (45 men; mean±SD age, 50.5±14.7 years). Higher QIDS and MADRS total scores were significantly associated with a greater PDQ total score (both p's",

keywords = "Depression, Illness severity, PDQ, Subjective cognitive impairment",

author = "Kyosuke Sawada and Kazunari Yoshida and Chisa Ozawa and Yuya Mizuno and Rubinstein, {Ellen B.} and Takefumi Suzuki and Masaru Mimura and Hiroyuki Uchida",

year = "2018",

month = dec,

day = "18",

doi = "10.1016/j.jad.2018.12.049",

language = "English",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Impact of subjective vs. objective remission status on subjective cognitive impairments in depression

AU - Sawada, Kyosuke

AU - Yoshida, Kazunari

AU - Ozawa, Chisa

AU - Mizuno, Yuya

AU - Rubinstein, Ellen B.

AU - Suzuki, Takefumi

AU - Mimura, Masaru

AU - Uchida, Hiroyuki

PY - 2018/12/18

Y1 - 2018/12/18

N2 - Objective The impact of subjective versus objective illness severity on subjective cognitive impairment in patients with depression has not been addressed. Methods This study is a post-hoc analysis of our cross-sectional study in Japanese outpatients with depressive disorder (ICD-10) (Ozawa et al., 2017). The participants received assessments with the Japanese version of the Perceived Deficits Questionnaire (J-PDQ), Quick Inventory of Depressive Symptomatology (QIDS), and Montgomery-Asberg Depression Rating Scale (MADRS). First, multiple regression analysis was conducted to examine the effects of demographic and clinical characteristics, including illness severity and medications (e.g., antidepressants and benzodiazepines), on the PDQ total score. Next, we categorized the participants into 4 groups based on the presence/absence of subjective and objective symptom remission (i.e., QIDS total score of ≤5 and MADRS total score of ≤9, respectively), and compared the differences in PDQ total scores between the QIDS- and MADRS-remitted group and the QIDS-non-remitted but MADRS-remitted group. Results 102 participants were included (45 men; mean±SD age, 50.5±14.7 years). Higher QIDS and MADRS total scores were significantly associated with a greater PDQ total score (both p's

AB - Objective The impact of subjective versus objective illness severity on subjective cognitive impairment in patients with depression has not been addressed. Methods This study is a post-hoc analysis of our cross-sectional study in Japanese outpatients with depressive disorder (ICD-10) (Ozawa et al., 2017). The participants received assessments with the Japanese version of the Perceived Deficits Questionnaire (J-PDQ), Quick Inventory of Depressive Symptomatology (QIDS), and Montgomery-Asberg Depression Rating Scale (MADRS). First, multiple regression analysis was conducted to examine the effects of demographic and clinical characteristics, including illness severity and medications (e.g., antidepressants and benzodiazepines), on the PDQ total score. Next, we categorized the participants into 4 groups based on the presence/absence of subjective and objective symptom remission (i.e., QIDS total score of ≤5 and MADRS total score of ≤9, respectively), and compared the differences in PDQ total scores between the QIDS- and MADRS-remitted group and the QIDS-non-remitted but MADRS-remitted group. Results 102 participants were included (45 men; mean±SD age, 50.5±14.7 years). Higher QIDS and MADRS total scores were significantly associated with a greater PDQ total score (both p's

KW - Depression

KW - Illness severity

KW - PDQ

KW - Subjective cognitive impairment

U2 - 10.1016/j.jad.2018.12.049

DO - 10.1016/j.jad.2018.12.049

M3 - Article

SN - 0165-0327

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Impact of subjective vs. objective remission status on subjective cognitive impairments in depression

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Keywords

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