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Impact of telephone delivered casemanagement on the effectiveness of collaborative care for depression and antidepressant use: A systematic review and meta-regression

Research output: Contribution to journalReview article

Joanna L. Hudson, Peter Bower, Evangelos Kontopantelis, Penny Bee, Janine Archer, Rose Clarke, Andrew S. Moriarty, David A. Richards, Simon Gilbody, Karina Lovell, Chris Dickens, Linda Gask, Waquas Waheed, Peter A. Coventry

Original languageEnglish
Article numbere0217948
JournalPLoS ONE
Issue number6
Early online date14 Jun 2019
Publication statusPublished - Jun 2019


King's Authors



The health service delivery framework collaborative care is an effective intervention for depression. However, uncertainties remain about how to optimise its delivery at scale. Structured case management is a core component of collaborative care; its delivery via the telephone may improve access.


To examine using meta-regression if telephone delivered case management diminishes the clinical effectiveness of collaborative care on depressive symptoms and anti-depressant use relative to face-to-face delivery methods.


Randomised controlled trials were eligible if they included collaborative care interventions for adults with depression identified using self-report measures or diagnostic interviews and reported depression outcomes. Sociodemographics, intervention characteristics, depressive symptoms, and anti-depressant use were extracted. Random effects univariable and multivariable meta-regression analyses were used to examine the moderating effect of telephone delivered case-management on outcomes.


Ninety-four trials were identified comprising of 103 comparisons across 24, 132 participants with depression outcomes and 67 comparisons from 15,367 participants with anti-depressant use outcomes. Telephone delivered case management did not diminish the effects of collaborative care on depressive symptoms (β = -0.01, 95% CI -0.12 to 0.10; p = 0.86). Telephone delivered case management decreased anti-depressant medication use (relative risk 0.76, 95% CI 0.63 to 0.92; p = 0.005); this effect remained when assessed simultaneously alongside other study-level moderators of collaborative care.


Using remote platforms such as the telephone to deliver case management may be a feasible way to implement collaborative care with no loss of effectiveness on depressive symptoms. However, adherence to anti-depressant medication may decrease when telephone case management is used.

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