@article{fc623f3d92d343b28966485559c5765e,
title = "Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy",
abstract = "Men with antisocial personality disorder (ASPD) with or without psychopathy (+/−P) are responsible for most violent crime in society. Development of effective treatments is hindered by poor understanding of the neurochemical underpinnings of the condition.Men with ASPD with and without psychopathy demonstrate impulsive decision-making, associated with striatal abnormalities in functional neuroimaging studies.However, to date, no study has directly examined the potential neurochemical underpinnings of such abnormalities. We therefore investigated striatal glutamate:GABA ratio using Magnetic Resonance Spectroscopy in 30 violent offenders(16ASPD-P,14ASPD+P) and 21 healthy non-offenders. Men with ASPD+/−P had a significant reduction in striatal glutamate:GABA ratio compared to non-offenders. We report, for the first time, striatal Glutamate/ GABA dysregulation in ASPD+/−P, and discuss how this may be related to core behavioral abnormalities in the disorders.",
author = "John Tully and Pereira, {Andreia C.} and Arjun Sethi and Julia Griem and Ben Cross and Williams, {Steve CR} and Blair, {Robert James} and Declan Murphy and Nigel Blackwood",
note = "Funding Information: This study was funded by Wellcome Clinical Research Training Fellowship grant for Dr John Tully, grant no. 200099/S/15/S. Additional funding of research team by National Institute for Health and Care Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King{\textquoteright}s College London, Medical Research Council, Autism Research for Europe (AIMS-2 Trials). The views expressed are those of the authors and not necessarily those of Wellcome Trust, MRC, NIHR, NHS or the Department of Health and Social Care. All authors declare no financial relationships or commercial interests in this work. We would like to acknowledge the input of Dr Adam Berrington in relation to the final draft of this work. Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
month = feb,
day = "7",
doi = "10.1038/s41380-024-02437-4",
language = "English",
volume = "29",
pages = "1824--1832",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "Springer Nature [academic journals on nature.com]",
number = "6",
}
