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Implementing a biogeographic ancestry inference service for forensic casework

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Implementing a biogeographic ancestry inference service for forensic casework. / Jin, Soulbee; Chase, Maretta; Henry, Margaret; Alderson, Gerry; Morrow, James M.; Malik, Sobia; Ballard, David; McGrory, Joel; Fernandopulle, Neil; Millman, Jonathan; Laird, Jack.

In: Electrophoresis, Vol. 39, No. 21, 11.2018, p. 2757-2765.

Research output: Contribution to journalArticle

Harvard

Jin, S, Chase, M, Henry, M, Alderson, G, Morrow, JM, Malik, S, Ballard, D, McGrory, J, Fernandopulle, N, Millman, J & Laird, J 2018, 'Implementing a biogeographic ancestry inference service for forensic casework', Electrophoresis, vol. 39, no. 21, pp. 2757-2765. https://doi.org/10.1002/elps.201800171

APA

Jin, S., Chase, M., Henry, M., Alderson, G., Morrow, J. M., Malik, S., Ballard, D., McGrory, J., Fernandopulle, N., Millman, J., & Laird, J. (2018). Implementing a biogeographic ancestry inference service for forensic casework. Electrophoresis, 39(21), 2757-2765. https://doi.org/10.1002/elps.201800171

Vancouver

Jin S, Chase M, Henry M, Alderson G, Morrow JM, Malik S et al. Implementing a biogeographic ancestry inference service for forensic casework. Electrophoresis. 2018 Nov;39(21):2757-2765. https://doi.org/10.1002/elps.201800171

Author

Jin, Soulbee ; Chase, Maretta ; Henry, Margaret ; Alderson, Gerry ; Morrow, James M. ; Malik, Sobia ; Ballard, David ; McGrory, Joel ; Fernandopulle, Neil ; Millman, Jonathan ; Laird, Jack. / Implementing a biogeographic ancestry inference service for forensic casework. In: Electrophoresis. 2018 ; Vol. 39, No. 21. pp. 2757-2765.

Bibtex Download

@article{3619d636532040ed86cc68f669c41f0d,
title = "Implementing a biogeographic ancestry inference service for forensic casework",
abstract = "The Centre of Forensic Sciences has validated the Precision ID Ancestry Panel on the Ion S5{\texttrademark} Massively Parallel Sequencing instrument for use in forensic casework. The focus of this paper is the development of reporting guidelines for implementation of the biogeographic ancestry inference service based on the Admixture Prediction results produced using the Torrent Suite{\texttrademark} Software (Thermo Fisher Scientific). The Admixture Prediction algorithm estimates the genetic ancestry of a sample using seven root populations (Europe, East Asia, Oceania, America, Africa, South Asia, and Southwest Asia). For individuals that declared a single ancestry, there was a high correlation between the declared ancestry and the ancestry predicted by the algorithm. However, some individuals with declared ancestries of Southern Europe, Southwest Asia, South Asia and Horn of Africa had Admixture Predictions that were composed of two or more root populations at 20% or greater. For individuals with known admixed ancestry, the major component of their declaration was included in their results in all but one case. Based on these results, reporting guidelines were developed and subsequently evaluated using the Admixture Predictions of additional samples. This paper discusses the development and evaluation of these reporting guidelines, along with an implementation plan for forensic casework.",
keywords = "Ancestry informative SNP, Biogeographic ancestry, Ion S5, Massively Parallel Sequencing, Precision ID Ancestry Panel",
author = "Soulbee Jin and Maretta Chase and Margaret Henry and Gerry Alderson and Morrow, {James M.} and Sobia Malik and David Ballard and Joel McGrory and Neil Fernandopulle and Jonathan Millman and Jack Laird",
year = "2018",
month = nov,
doi = "10.1002/elps.201800171",
language = "English",
volume = "39",
pages = "2757--2765",
journal = "Electrophoresis",
issn = "0173-0835",
number = "21",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Implementing a biogeographic ancestry inference service for forensic casework

AU - Jin, Soulbee

AU - Chase, Maretta

AU - Henry, Margaret

AU - Alderson, Gerry

AU - Morrow, James M.

AU - Malik, Sobia

AU - Ballard, David

AU - McGrory, Joel

AU - Fernandopulle, Neil

AU - Millman, Jonathan

AU - Laird, Jack

PY - 2018/11

Y1 - 2018/11

N2 - The Centre of Forensic Sciences has validated the Precision ID Ancestry Panel on the Ion S5™ Massively Parallel Sequencing instrument for use in forensic casework. The focus of this paper is the development of reporting guidelines for implementation of the biogeographic ancestry inference service based on the Admixture Prediction results produced using the Torrent Suite™ Software (Thermo Fisher Scientific). The Admixture Prediction algorithm estimates the genetic ancestry of a sample using seven root populations (Europe, East Asia, Oceania, America, Africa, South Asia, and Southwest Asia). For individuals that declared a single ancestry, there was a high correlation between the declared ancestry and the ancestry predicted by the algorithm. However, some individuals with declared ancestries of Southern Europe, Southwest Asia, South Asia and Horn of Africa had Admixture Predictions that were composed of two or more root populations at 20% or greater. For individuals with known admixed ancestry, the major component of their declaration was included in their results in all but one case. Based on these results, reporting guidelines were developed and subsequently evaluated using the Admixture Predictions of additional samples. This paper discusses the development and evaluation of these reporting guidelines, along with an implementation plan for forensic casework.

AB - The Centre of Forensic Sciences has validated the Precision ID Ancestry Panel on the Ion S5™ Massively Parallel Sequencing instrument for use in forensic casework. The focus of this paper is the development of reporting guidelines for implementation of the biogeographic ancestry inference service based on the Admixture Prediction results produced using the Torrent Suite™ Software (Thermo Fisher Scientific). The Admixture Prediction algorithm estimates the genetic ancestry of a sample using seven root populations (Europe, East Asia, Oceania, America, Africa, South Asia, and Southwest Asia). For individuals that declared a single ancestry, there was a high correlation between the declared ancestry and the ancestry predicted by the algorithm. However, some individuals with declared ancestries of Southern Europe, Southwest Asia, South Asia and Horn of Africa had Admixture Predictions that were composed of two or more root populations at 20% or greater. For individuals with known admixed ancestry, the major component of their declaration was included in their results in all but one case. Based on these results, reporting guidelines were developed and subsequently evaluated using the Admixture Predictions of additional samples. This paper discusses the development and evaluation of these reporting guidelines, along with an implementation plan for forensic casework.

KW - Ancestry informative SNP

KW - Biogeographic ancestry

KW - Ion S5

KW - Massively Parallel Sequencing

KW - Precision ID Ancestry Panel

UR - http://www.scopus.com/inward/record.url?scp=85052821152&partnerID=8YFLogxK

U2 - 10.1002/elps.201800171

DO - 10.1002/elps.201800171

M3 - Article

C2 - 30125362

AN - SCOPUS:85052821152

VL - 39

SP - 2757

EP - 2765

JO - Electrophoresis

JF - Electrophoresis

SN - 0173-0835

IS - 21

ER -

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