Implications of a positive sentinel node in oral squamous cell carcinoma

Benjamin A S Gurney; Clare Schilling; Venkata Putcha; Lee W Alkureishi; Amezaga J Alvarez; Vivi Bakholdt; Luis Barbier Herrero; Luigi Barzan; Anders Bilde; Elisabeth Bloemena; Carmen Camarero Salces; Paolo Dalla Palma; Remco de Bree; Didier Dequanter; Gilles Dolivet; Davide Donner; Geke B Flach; Manuel Fresno; Cesare Grandi; Stephan Haerle; Gerhard F Huber; Keith Hunter; George Lawson; Agnes Leroux; Phillippe H Lothaire; Gerard Mamelle; Enrico M Silini; Romina Mastronicola; Edward W Odell; Michael J O'Doherty; Tito Poli; Siavash Rahimi; Gary L Ross; J Santamaria Zuazua; Simone Santini; Lars Sebbesen; Taimur Shoaib; Philip Sloan; Jens Ahm Sorensen; David S Soutar; Marianne H Therkildsen; Maurizio Giovanni Vigili; Pedro M Villarreal; Christian von Buchwald; Jochen A Werner; Susanne Wiegand; Mark McGurk

doi:10.1002/hed.21973

Implications of a positive sentinel node in oral squamous cell carcinoma

Benjamin A S Gurney, Clare Schilling, Venkata Putcha, Lee W Alkureishi, Amezaga J Alvarez, Vivi Bakholdt, Luis Barbier Herrero, Luigi Barzan, Anders Bilde, Elisabeth Bloemena, Carmen Camarero Salces, Paolo Dalla Palma, Remco de Bree, Didier Dequanter, Gilles Dolivet, Davide Donner, Geke B Flach, Manuel Fresno, Cesare Grandi, Stephan HaerleGerhard F Huber, Keith Hunter, George Lawson, Agnes Leroux, Phillippe H Lothaire, Gerard Mamelle, Enrico M Silini, Romina Mastronicola, Edward W Odell, Michael J O'Doherty, Tito Poli, Siavash Rahimi, Gary L Ross, J Santamaria Zuazua, Simone Santini, Lars Sebbesen, Taimur Shoaib, Philip Sloan, Jens Ahm Sorensen, David S Soutar, Marianne H Therkildsen, Maurizio Giovanni Vigili, Pedro M Villarreal, Christian von Buchwald, Jochen A Werner, Susanne Wiegand, Mark McGurk

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Abstract

Background
The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Methods
In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.

Results
A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.

Conclusions
The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. © 2012 Wiley Periodicals, Inc. Head Neck, 2012

Original language	English
Pages (from-to)	1580–1585
Journal	Cme Bulletin Otorhinolaryngology Head & Neck Surgery
Volume	34
Issue number	11
Early online date	31 Jan 2012
DOIs	https://doi.org/10.1002/hed.21973
Publication status	Published - Nov 2012

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Gurney, B. A. S., Schilling, C., Putcha, V., Alkureishi, L. W., Alvarez, A. J., Bakholdt, V., Barbier Herrero, L., Barzan, L., Bilde, A., Bloemena, E., Salces, C. C., Palma, P. D., de Bree, R., Dequanter, D., Dolivet, G., Donner, D., Flach, G. B., Fresno, M., Grandi, C., ... McGurk, M. (2012). Implications of a positive sentinel node in oral squamous cell carcinoma. Cme Bulletin Otorhinolaryngology Head & Neck Surgery, 34(11), 1580–1585. https://doi.org/10.1002/hed.21973

@article{24a5a814d36d46ccbea7221005d2e935,

title = "Implications of a positive sentinel node in oral squamous cell carcinoma",

abstract = "BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. {\textcopyright} 2012 Wiley Periodicals, Inc. Head Neck, 2012",

author = "Gurney, {Benjamin A S} and Clare Schilling and Venkata Putcha and Alkureishi, {Lee W} and Alvarez, {Amezaga J} and Vivi Bakholdt and {Barbier Herrero}, Luis and Luigi Barzan and Anders Bilde and Elisabeth Bloemena and Salces, {Carmen Camarero} and Palma, {Paolo Dalla} and {de Bree}, Remco and Didier Dequanter and Gilles Dolivet and Davide Donner and Flach, {Geke B} and Manuel Fresno and Cesare Grandi and Stephan Haerle and Huber, {Gerhard F} and Keith Hunter and George Lawson and Agnes Leroux and Lothaire, {Phillippe H} and Gerard Mamelle and Silini, {Enrico M} and Romina Mastronicola and Odell, {Edward W} and O'Doherty, {Michael J} and Tito Poli and Siavash Rahimi and Ross, {Gary L} and Zuazua, {J Santamaria} and Simone Santini and Lars Sebbesen and Taimur Shoaib and Philip Sloan and Sorensen, {Jens Ahm} and Soutar, {David S} and Therkildsen, {Marianne H} and Vigili, {Maurizio Giovanni} and Villarreal, {Pedro M} and {von Buchwald}, Christian and Werner, {Jochen A} and Susanne Wiegand and Mark McGurk",

note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",

year = "2012",

month = nov,

doi = "10.1002/hed.21973",

language = "English",

volume = "34",

pages = "1580–1585",

journal = "Cme Bulletin Otorhinolaryngology Head & Neck Surgery",

publisher = "Rila Publications Ltd",

number = "11",

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Gurney, BAS, Schilling, C, Putcha, V, Alkureishi, LW, Alvarez, AJ, Bakholdt, V, Barbier Herrero, L, Barzan, L, Bilde, A, Bloemena, E, Salces, CC, Palma, PD, de Bree, R, Dequanter, D, Dolivet, G, Donner, D, Flach, GB, Fresno, M, Grandi, C, Haerle, S, Huber, GF, Hunter, K, Lawson, G, Leroux, A, Lothaire, PH, Mamelle, G, Silini, EM, Mastronicola, R, Odell, EW , O'Doherty, MJ, Poli, T, Rahimi, S, Ross, GL, Zuazua, JS, Santini, S, Sebbesen, L, Shoaib, T, Sloan, P, Sorensen, JA, Soutar, DS, Therkildsen, MH, Vigili, MG, Villarreal, PM, von Buchwald, C, Werner, JA, Wiegand, S & McGurk, M 2012, 'Implications of a positive sentinel node in oral squamous cell carcinoma', Cme Bulletin Otorhinolaryngology Head & Neck Surgery, vol. 34, no. 11, pp. 1580–1585. https://doi.org/10.1002/hed.21973

TY - JOUR

T1 - Implications of a positive sentinel node in oral squamous cell carcinoma

AU - Gurney, Benjamin A S

AU - Schilling, Clare

AU - Putcha, Venkata

AU - Alkureishi, Lee W

AU - Alvarez, Amezaga J

AU - Bakholdt, Vivi

AU - Barbier Herrero, Luis

AU - Barzan, Luigi

AU - Bilde, Anders

AU - Bloemena, Elisabeth

AU - Salces, Carmen Camarero

AU - Palma, Paolo Dalla

AU - de Bree, Remco

AU - Dequanter, Didier

AU - Dolivet, Gilles

AU - Donner, Davide

AU - Flach, Geke B

AU - Fresno, Manuel

AU - Grandi, Cesare

AU - Haerle, Stephan

AU - Huber, Gerhard F

AU - Hunter, Keith

AU - Lawson, George

AU - Leroux, Agnes

AU - Lothaire, Phillippe H

AU - Mamelle, Gerard

AU - Silini, Enrico M

AU - Mastronicola, Romina

AU - Odell, Edward W

AU - O'Doherty, Michael J

AU - Poli, Tito

AU - Rahimi, Siavash

AU - Ross, Gary L

AU - Zuazua, J Santamaria

AU - Santini, Simone

AU - Sebbesen, Lars

AU - Shoaib, Taimur

AU - Sloan, Philip

AU - Sorensen, Jens Ahm

AU - Soutar, David S

AU - Therkildsen, Marianne H

AU - Vigili, Maurizio Giovanni

AU - Villarreal, Pedro M

AU - von Buchwald, Christian

AU - Werner, Jochen A

AU - Wiegand, Susanne

AU - McGurk, Mark

PY - 2012/11

Y1 - 2012/11

N2 - BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. © 2012 Wiley Periodicals, Inc. Head Neck, 2012

AB - BackgroundThe role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.MethodsIn all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.ResultsA total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.ConclusionsThe results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. © 2012 Wiley Periodicals, Inc. Head Neck, 2012

U2 - 10.1002/hed.21973

DO - 10.1002/hed.21973

M3 - Article

C2 - 22290737

VL - 34

SP - 1580

EP - 1585

JO - Cme Bulletin Otorhinolaryngology Head & Neck Surgery

JF - Cme Bulletin Otorhinolaryngology Head & Neck Surgery

IS - 11

ER -

Implications of a positive sentinel node in oral squamous cell carcinoma

Abstract

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