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Implications of a positive sentinel node in oral squamous cell carcinoma

Research output: Contribution to journalArticle

Benjamin A S Gurney, Clare Schilling, Venkata Putcha, Lee W Alkureishi, Amezaga J Alvarez, Vivi Bakholdt, Luis Barbier Herrero, Luigi Barzan, Anders Bilde, Elisabeth Bloemena, Carmen Camarero Salces, Paolo Dalla Palma, Remco de Bree, Didier Dequanter, Gilles Dolivet, Davide Donner, Geke B Flach, Manuel Fresno, Cesare Grandi, Stephan Haerle & 27 others Gerhard F Huber, Keith Hunter, George Lawson, Agnes Leroux, Phillippe H Lothaire, Gerard Mamelle, Enrico M Silini, Romina Mastronicola, Edward W Odell, Michael J O'Doherty, Tito Poli, Siavash Rahimi, Gary L Ross, J Santamaria Zuazua, Simone Santini, Lars Sebbesen, Taimur Shoaib, Philip Sloan, Jens Ahm Sorensen, David S Soutar, Marianne H Therkildsen, Maurizio Giovanni Vigili, Pedro M Villarreal, Christian von Buchwald, Jochen A Werner, Susanne Wiegand, Mark McGurk

Original languageEnglish
Pages (from-to)1580–1585
JournalCme Bulletin Otorhinolaryngology Head & Neck Surgery
Volume34
Issue number11
Early online date31 Jan 2012
DOIs
StatePublished - Nov 2012

King's Authors

Abstract

Background
The role of sentinel node biopsy in head and neck cancer is currently being explored. Patients with positive sentinel nodes were investigated to establish if additional metastases were present in the neck, their distribution, and their impact on outcome.

Methods
In all, 109 patients (n = 109) from 15 European centers, with cT1/2,N0 tumors, and a positive sentinel lymph node were identified. Kaplan–Meier and univariate and multivariate logistic regression analysis were used to identify variables that predicted for additional positive nodes and their position within the neck.

Results
A total of 122 neck dissections were performed in 109 patients. Additional positive nodes were found in 34.4% of cases (42/122: 18 same, 21 adjacent, and 3 nonadjacent neck level). Additional nodes, especially if outside the sentinel node basin, had an impact on outcome.

Conclusions
The results are preliminary but suggest that both the number and the position of positive sentinel nodes may identify different prognostic groups that may allow further tailoring of management plans. © 2012 Wiley Periodicals, Inc. Head Neck, 2012

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