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Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study

Research output: Contribution to journalArticle

Ariana Gatt, Antigoni Ekonomou, Alyma Somani, Sandrine Thuret, David Howlett, Anne Corbett, Mary Johnson, Elaine Perry, Johannes Attems, Paul Francis, Dag Aarsland, Clive Ballard

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalDementia and Geriatric Cognitive Disorders
Issue number5-6
Early online date27 Jan 2018
Publication statusE-pub ahead of print - 27 Jan 2018

King's Authors


OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD).

METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs).

RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores.

CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.

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