Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

Justin Davies; Nearchos Hadjiloizou; D Leibovich; A Malaweera; Jordi Alastruey-Arimon; Zachary I. Whinnett; Charlotte H. Manisty; Darrel P. Francis; Jazmin Aguado-Sierra; Rodney A. Foale; Iqbal S. Malik; Kim Parker; Jamil Mayet; Alun Hughes

doi:10.1016/j.artres.2007.08.001

Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

Justin Davies, Nearchos Hadjiloizou, D Leibovich , A Malaweera , Jordi Alastruey-Arimon, Zachary I. Whinnett, Charlotte H. Manisty, Darrel P. Francis, Jazmin Aguado-Sierra, Rodney A. Foale, Iqbal S. Malik, Kim Parker, Jamil Mayet, Alun Hughes

Biomedical Engineering Department

Research output: Contribution to journal › Article › peer-review

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Abstract

It has been recognized for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir-wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.

Original language	English
Pages (from-to)	40–45
Number of pages	6
Journal	Artery Research
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.artres.2007.08.001
Publication status	Published - Sept 2007

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Davies, J., Hadjiloizou, N., Leibovich , D., Malaweera , A., Alastruey-Arimon, J., Whinnett, Z. I., Manisty, C. H., Francis, D. P., Aguado-Sierra, J., Foale, R. A., Malik, I. S., Parker, K., Mayet, J., & Hughes, A. (2007). Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank. Artery Research, 1(2), 40–45. https://doi.org/10.1016/j.artres.2007.08.001

@article{bad4b76dc28148e395984eb4647e7905,

title = "Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank",

abstract = "It has been recognized for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of {\textquoteleft}self-cancelling{\textquoteright} forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir-wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.",

author = "Justin Davies and Nearchos Hadjiloizou and D Leibovich and A Malaweera and Jordi Alastruey-Arimon and Whinnett, {Zachary I.} and Manisty, {Charlotte H.} and Francis, {Darrel P.} and Jazmin Aguado-Sierra and Foale, {Rodney A.} and Malik, {Iqbal S.} and Kim Parker and Jamil Mayet and Alun Hughes",

year = "2007",

month = sep,

doi = "10.1016/j.artres.2007.08.001",

language = "English",

volume = "1",

pages = "40–45",

journal = "Artery Research",

issn = "1872-9312",

publisher = "Elsevier BV",

number = "2",

}

Davies, J, Hadjiloizou, N, Leibovich , D, Malaweera , A, Alastruey-Arimon, J, Whinnett, ZI, Manisty, CH, Francis, DP, Aguado-Sierra, J, Foale, RA, Malik, IS, Parker, K, Mayet, J & Hughes, A 2007, 'Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank', Artery Research, vol. 1, no. 2, pp. 40–45. https://doi.org/10.1016/j.artres.2007.08.001

TY - JOUR

T1 - Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

AU - Davies, Justin

AU - Hadjiloizou, Nearchos

AU - Leibovich , D

AU - Malaweera , A

AU - Alastruey-Arimon, Jordi

AU - Whinnett, Zachary I.

AU - Manisty, Charlotte H.

AU - Francis, Darrel P.

AU - Aguado-Sierra, Jazmin

AU - Foale, Rodney A.

AU - Malik, Iqbal S.

AU - Parker, Kim

AU - Mayet, Jamil

AU - Hughes, Alun

PY - 2007/9

Y1 - 2007/9

N2 - It has been recognized for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir-wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.

AB - It has been recognized for nearly 200 years that the human pressure waveform changes in shape with ageing and disease. The shape of the pressure waveform has been explained in terms of two fundamental models: the Windkessel (reservoir) and wave theory. In its simplest form the Windkessel model satisfactorily explains the pressure waveform in diastole but cannot model pressure changes in systole. Wave theory satisfactorily models the pressure waveform but predicts the existence of ‘self-cancelling’ forward and backward waves in diastole which are difficult to explain in biological terms. We propose that a hybrid reservoir-wave model better describes the pressure waveform and may enable assessment of aortic function from pressure measurements made at any large systemic artery.

U2 - 10.1016/j.artres.2007.08.001

DO - 10.1016/j.artres.2007.08.001

M3 - Article

SN - 1872-9312

VL - 1

SP - 40

EP - 45

JO - Artery Research

JF - Artery Research

IS - 2

ER -

Importance of the aortic reservoir in determining the shape of the arterial pressure waveform – The forgotten lessons of Frank

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