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Improved Placental Parameter Estimation Using Data-Driven Bayesian Modelling

Research output: Chapter in Book/Report/Conference proceedingConference paperpeer-review

Dimitra Flouri, David Owen, Rosalind Aughwane, Nada Mufti, Magdalena Sokolska, David Atkinson, Giles Kendall, Alan Bainbridge, Tom Vercauteren, Anna L. David, Sebastien Ourselin, Andrew Melbourne

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings
EditorsDinggang Shen, Pew-Thian Yap, Tianming Liu, Terry M. Peters, Ali Khan, Lawrence H. Staib, Caroline Essert, Sean Zhou
Number of pages8
ISBN (Print)9783030322472
Event22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019 - Shenzhen, China
Duration: 13 Oct 201917 Oct 2019

Publication series

NameLecture Notes in Computer Science


Conference22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019

King's Authors


The placenta plays a key contribution to successful pregnancy outcome. New MR imaging techniques are able to reveal intricate details about placental structure and function and measure placental blood flow and feto-placental oxygenation. Placental diffusion-weighted MRI is however challenging due to maternal breathing motion and poor signal-to-noise ratio making motion correction important for subsequent quantitative analysis. In this work, we (i) introduce an iterative model-based registration technique which incorporates a placenta-specific model into the motion correction process and (ii) describe a new technique making use of a Bayesian shrinkage prior to obtain robust estimates of individual and population trends in parameters. Our results suggest that the proposed registration method improves alignment of placental data and that the Bayesian fitting technique allows the estimation of voxel-level placenta flow parameters and the population trend in each parameter with gestational age (GA). We report gestational age dependent differences in vascular compartments and fetal oxygen saturation values observed across 9 normally grown pregnancies between 25–34 weeks gestational age and show qualitatively improved parameter mapping and more precise longitudinal fitting. Fetal oxygen saturation is observed to decrease at This technique provides a robust framework for analysing longitudinal changes in both normal and pathological placental function.

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