Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation

TY - JOUR

T1 - Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation

AU - Heckemann, Rolf A.

AU - Keihaninejad, Shiva

AU - Aljabar, Paul

AU - Rueckert, Daniel

AU - Hajnal, Jo

AU - Hammers, Alexander

AU - Alzheimer's Dis Neuroimaging Initi

PY - 2010/5/15

Y1 - 2010/5/15

N2 - Automatic anatomical segmentation of magnetic resonance human brain images has been shown to be accurate and robust when based on multiple atlases that encompass the anatomical variability of the cohort of subjects. We observed that the method tends to fail when the segmentation target shows ventricular enlargement that is not captured by the atlas database. By incorporating tissue classification information into the image registration process, we aimed to increase the robustness of the method. For testing, subjects who participated in the Oxford Project to Investigate Memory and Aging (OPTIMA) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) were selected for ventriculomegaly. Segmentation quality was substantially improved in the ventricles and surrounding structures (9/9 successes on visual rating versus 4/9 successes using the baseline method). In addition, the modification resulted in a significant increase of segmentation accuracy in healthy subjects' brain images. Hippocampal segmentation results in a group of patients with temporal lobe epilepsy were near identical with both approaches. The modified approach (MAPER, multiatlas propagation with enhanced registration) extends the applicability of multi-atlas based automatic whole-brain segmentation to subjects with ventriculomegaly, as seen in normal aging as well as in numerous neurodegenerative diseases. (C) 2010 Elsevier Inc. All rights reserved.

AB - Automatic anatomical segmentation of magnetic resonance human brain images has been shown to be accurate and robust when based on multiple atlases that encompass the anatomical variability of the cohort of subjects. We observed that the method tends to fail when the segmentation target shows ventricular enlargement that is not captured by the atlas database. By incorporating tissue classification information into the image registration process, we aimed to increase the robustness of the method. For testing, subjects who participated in the Oxford Project to Investigate Memory and Aging (OPTIMA) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) were selected for ventriculomegaly. Segmentation quality was substantially improved in the ventricles and surrounding structures (9/9 successes on visual rating versus 4/9 successes using the baseline method). In addition, the modification resulted in a significant increase of segmentation accuracy in healthy subjects' brain images. Hippocampal segmentation results in a group of patients with temporal lobe epilepsy were near identical with both approaches. The modified approach (MAPER, multiatlas propagation with enhanced registration) extends the applicability of multi-atlas based automatic whole-brain segmentation to subjects with ventriculomegaly, as seen in normal aging as well as in numerous neurodegenerative diseases. (C) 2010 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.neuroimage.2010.01.072

DO - 10.1016/j.neuroimage.2010.01.072

M3 - Article

SN - 1053-8119

VL - 51

SP - 221

EP - 227

JO - NeuroImage

JF - NeuroImage

IS - 1

ER -