In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius poiret

M R Loizzo; R Tundis; G A Statti; F Menichini; P J Houghton

doi:10.1211/0022357056398

In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius poiret

M R Loizzo, R Tundis, G A Statti, F Menichini, P J Houghton

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Abstract

We have studied the cytotoxic activity of extracts and jacaranone from Senecio leucanthemifolius Poiret. Extracts from S. leucanthemifolius were able to inhibit the in-vitro proliferation of a series of human tumour cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with an IC50 of 20.1 mu g mL(-1) on the large cell carcinoma cell line COR-L23. The ethyl acetate extract showed an IC50 value of 5.0 mu g mL(-1) and the butanol extract an IC50 value of 6.4 mu g mL(-1) on the same cell line. A major active constituent of the dichloromethane extract was shown to be jacaranone, which was demonstrated to have a very strong activity against all of the tumour cell lines with IC50 values between 2.86 and 3.85 mu g mL(-1), although it did not account for all the activity observed. Constituents of S. leucanthemifolius extracts were identified by GC/MS analysis and NMR

Original language	English
Pages (from-to)	897 - 901
Number of pages	5
Journal	Journal of Pharmacy and Pharmacology
Volume	57
Issue number	7
DOIs	https://doi.org/10.1211/0022357056398
Publication status	Published - Jul 2005

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@article{3c1d7c192cf84c8581529727015d4985,

title = "In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius poiret",

abstract = "We have studied the cytotoxic activity of extracts and jacaranone from Senecio leucanthemifolius Poiret. Extracts from S. leucanthemifolius were able to inhibit the in-vitro proliferation of a series of human tumour cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with an IC50 of 20.1 mu g mL(-1) on the large cell carcinoma cell line COR-L23. The ethyl acetate extract showed an IC50 value of 5.0 mu g mL(-1) and the butanol extract an IC50 value of 6.4 mu g mL(-1) on the same cell line. A major active constituent of the dichloromethane extract was shown to be jacaranone, which was demonstrated to have a very strong activity against all of the tumour cell lines with IC50 values between 2.86 and 3.85 mu g mL(-1), although it did not account for all the activity observed. Constituents of S. leucanthemifolius extracts were identified by GC/MS analysis and NMR",

author = "Loizzo, {M R} and R Tundis and Statti, {G A} and F Menichini and Houghton, {P J}",

year = "2005",

month = jul,

doi = "10.1211/0022357056398",

language = "English",

volume = "57",

pages = "897 -- 901",

journal = "Journal of Pharmacy and Pharmacology",

publisher = "Wiley-Blackwell",

number = "7",

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TY - JOUR

T1 - In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius poiret

AU - Loizzo, M R

AU - Tundis, R

AU - Statti, G A

AU - Menichini, F

AU - Houghton, P J

PY - 2005/7

Y1 - 2005/7

N2 - We have studied the cytotoxic activity of extracts and jacaranone from Senecio leucanthemifolius Poiret. Extracts from S. leucanthemifolius were able to inhibit the in-vitro proliferation of a series of human tumour cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with an IC50 of 20.1 mu g mL(-1) on the large cell carcinoma cell line COR-L23. The ethyl acetate extract showed an IC50 value of 5.0 mu g mL(-1) and the butanol extract an IC50 value of 6.4 mu g mL(-1) on the same cell line. A major active constituent of the dichloromethane extract was shown to be jacaranone, which was demonstrated to have a very strong activity against all of the tumour cell lines with IC50 values between 2.86 and 3.85 mu g mL(-1), although it did not account for all the activity observed. Constituents of S. leucanthemifolius extracts were identified by GC/MS analysis and NMR

AB - We have studied the cytotoxic activity of extracts and jacaranone from Senecio leucanthemifolius Poiret. Extracts from S. leucanthemifolius were able to inhibit the in-vitro proliferation of a series of human tumour cell lines. The dichloromethane extract demonstrated effective cytotoxic activity with an IC50 of 20.1 mu g mL(-1) on the large cell carcinoma cell line COR-L23. The ethyl acetate extract showed an IC50 value of 5.0 mu g mL(-1) and the butanol extract an IC50 value of 6.4 mu g mL(-1) on the same cell line. A major active constituent of the dichloromethane extract was shown to be jacaranone, which was demonstrated to have a very strong activity against all of the tumour cell lines with IC50 values between 2.86 and 3.85 mu g mL(-1), although it did not account for all the activity observed. Constituents of S. leucanthemifolius extracts were identified by GC/MS analysis and NMR

U2 - 10.1211/0022357056398

DO - 10.1211/0022357056398

M3 - Article

VL - 57

SP - 897

EP - 901

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

IS - 7

ER -

In-vitro antiproliferative effects on human tumour cell lines of extracts and jacaranone from Senecio leucanthemifolius poiret

Abstract

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