In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue

TY - JOUR

T1 - In vitro assessment of the agonist properties of the novel 5-HT1A receptor ligand, CUMI-101 (MMP), in rat brain tissue

AU - Hendry, Nicola

AU - Christie, Isabel

AU - Rabiner, Eugenii Alfredovich

AU - Laruelle, Marc

AU - Watson, Jeannette

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/2

Y1 - 2011/2

N2 - Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. [(11)C]CUMI-101, proposed as the first 5-HT(1A) receptor agonist PET ligand, has been reported to behave as a potent 5-HT(1A) agonist in a cellular system stably expressing human recombinant 5-HT(1A) receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue.

AB - Development of agonist positron emission tomography (PET) radioligands for the 5-HT neurotransmitter system is an important target to enable the understanding of human 5-HT function in vivo. [(11)C]CUMI-101, proposed as the first 5-HT(1A) receptor agonist PET ligand, has been reported to behave as a potent 5-HT(1A) agonist in a cellular system stably expressing human recombinant 5-HT(1A) receptors. In this study, we investigate the agonist properties of CUMI-101 in rat brain tissue.

U2 - 10.1016/j.nucmedbio.2010.08.003

DO - 10.1016/j.nucmedbio.2010.08.003

M3 - Article

C2 - 21315283

VL - 38

SP - 273

EP - 277

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 2

ER -