In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

A Itharat; P J Houghton; E Eno-Amooquaye; P J Burke; J H Sampson; A Raman

doi:10.1016/j.jep.2003.09.014

In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

A Itharat, P J Houghton, E Eno-Amooquaye, P J Burke, J H Sampson, A Raman

Research output: Contribution to journal › Article › peer-review

224 Citations (Scopus)

Abstract

The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of I I Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	33 - 38
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	90
Issue number	1
DOIs	https://doi.org/10.1016/j.jep.2003.09.014
Publication status	Published - Jan 2004

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abstract = "The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of I I Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types. (C) 2003 Elsevier Ireland Ltd. All rights reserved.",

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T1 - In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

AU - Itharat, A

AU - Houghton, P J

AU - Eno-Amooquaye, E

AU - Burke, P J

AU - Sampson, J H

AU - Raman, A

PY - 2004/1

Y1 - 2004/1

N2 - The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of I I Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

AB - The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of I I Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

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In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer

Abstract

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