In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance

Shuiping Jiang; Dela Golshayan; Julia Tsang; Giovanna Lombardi; Robert I Lechler

doi:10.1016/j.intimp.2006.07.025

In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance

Shuiping Jiang, Dela Golshayan, Julia Tsang, Giovanna Lombardi, Robert I Lechler

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.

Original language	English
Pages (from-to)	1879 - 1882
Number of pages	4
Journal	INTERNATIONAL IMMUNOPHARMACOLOGY
Volume	6
Issue number	13-14
Early online date	15 Aug 2006
DOIs	https://doi.org/10.1016/j.intimp.2006.07.025
Publication status	Published - 20 Dec 2006

Access to Document

10.1016/j.intimp.2006.07.025

Cite this

@article{090ed81ba97243e092d51aa929f8312e,

title = "In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance",

abstract = "The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.",

author = "Shuiping Jiang and Dela Golshayan and Julia Tsang and Giovanna Lombardi and Lechler, {Robert I}",

year = "2006",

month = dec,

day = "20",

doi = "10.1016/j.intimp.2006.07.025",

language = "English",

volume = "6",

pages = "1879 -- 1882",

journal = "INTERNATIONAL IMMUNOPHARMACOLOGY",

publisher = "Elsevier",

number = "13-14",

}

TY - JOUR

T1 - In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance

AU - Jiang, Shuiping

AU - Golshayan, Dela

AU - Tsang, Julia

AU - Lombardi, Giovanna

AU - Lechler, Robert I

PY - 2006/12/20

Y1 - 2006/12/20

N2 - The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.

AB - The key goal in clinical transplantation is the induction of donor-specific transplantation tolerance to minimise the morbidity and mortality associated with long-term immunosuppression. Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor FoxP3 play a crucial role in the prevention of autoimmunity, and appear to mediate transplantation tolerance, and these cells can have indirect allospecificity for donor antigens. Here we show that self-reactive human CD4(+)CD25(+) Tregs can be subverted into allopeptide-specific cells in vitro and be expanded to large cell numbers, and that similar in vitro expanded murine CD4(+)CD25(+) Tregs with indirect allospecificity were capable of inducing donor-specific experimental transplantation tolerance. These data provide a platform for clinical studies using CD4(+)CD25(+) Tregs with indirect allospecificity as potential reagents for the induction of donor-specific transplantation tolerance.

U2 - 10.1016/j.intimp.2006.07.025

DO - 10.1016/j.intimp.2006.07.025

M3 - Article

C2 - 17161340

VL - 6

SP - 1879

EP - 1882

JO - INTERNATIONAL IMMUNOPHARMACOLOGY

JF - INTERNATIONAL IMMUNOPHARMACOLOGY

IS - 13-14

ER -

In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance

Abstract

Access to Document

Fingerprint

Cite this