In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae

TY - JOUR

T1 - In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae

AU - Amara, Flavio

AU - Colombo, Riccardo

AU - Cazzaniga, Paolo

AU - Pescini, Dario

AU - Csikász-Nagy, Attila

AU - Falconi, Marco Muzi

AU - Besozzi, Daniela

AU - Plevani, Paolo

PY - 2013

Y1 - 2013

N2 - The genome of living organisms is constantly exposed to several damaging agents that induce different types of DNA lesions, leading to cellular malfunctioning and onset of many diseases. To maintain genome stability, cells developed various repair and tolerance systems to counteract the effects of DNA damage. Here we focus on Post Replication Repair (PRR), the pathway involved in the bypass of DNA lesions induced by sunlight exposure and UV radiation. PRR acts through two different mechanisms, activated by mono- and poly-ubiquitylation of the DNA sliding clamp, called Proliferating Cell Nuclear Antigen (PCNA).

AB - The genome of living organisms is constantly exposed to several damaging agents that induce different types of DNA lesions, leading to cellular malfunctioning and onset of many diseases. To maintain genome stability, cells developed various repair and tolerance systems to counteract the effects of DNA damage. Here we focus on Post Replication Repair (PRR), the pathway involved in the bypass of DNA lesions induced by sunlight exposure and UV radiation. PRR acts through two different mechanisms, activated by mono- and poly-ubiquitylation of the DNA sliding clamp, called Proliferating Cell Nuclear Antigen (PCNA).

U2 - 10.1186/1752-0509-7-24

DO - 10.1186/1752-0509-7-24

M3 - Article

C2 - 23514624

SN - 1752-0509

VL - 7

SP - 24

JO - Bmc Systems Biology

JF - Bmc Systems Biology

ER -