In vivo reprogramming for tissue repair

TY - JOUR

T1 - In vivo reprogramming for tissue repair

AU - Heinrich, Christophe

AU - Spagnoli, Francesca M.

AU - Berninger, Benedikt

PY - 2015/2/27

Y1 - 2015/2/27

N2 - Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic β-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.

AB - Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic β-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.

U2 - 10.1038/ncb3108

DO - 10.1038/ncb3108

M3 - Review article

SN - 1465-7392

VL - 17

SP - 204

EP - 211

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 3

ER -