In vivo reprogramming for tissue repair

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)

Abstract

Vital organs such as the pancreas and the brain lack the capacity for effective regeneration. To overcome this limitation, an emerging strategy consists of converting resident tissue-specific cells into the cell types that are lost due to disease by a process called in vivo lineage reprogramming. Here we discuss recent breakthroughs in regenerating pancreatic β-cells and neurons from various cell types, and highlight fundamental challenges that need to be overcome for the translation of in vivo lineage reprogramming into therapy.
Original languageEnglish
Pages (from-to)204-211
Number of pages8
JournalNature Cell Biology
Volume17
Issue number3
DOIs
Publication statusPublished - 27 Feb 2015

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