In-vivo T2 measurements of the Fetal Brain Using Single-Shot Fast Spin Echo Sequences

Suryava Bhattacharya*, Anthony Price, Alena Uus, Helena Sousa, Massimo Marenzana, Kathleen Colford, Peter Murkin, Maggie Lee, Lucilio Cordero Grande, Rui Pedro A. G. Teixeira, Shaihan Malik, Maria Deprez

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We propose a quantitative framework for motion-corrected T2 fetal brain measurements in vivo and validate the single-shot fast spin echo (SS-FSE) sequence to perform these measurements.

Stacks of two-dimensional SS-FSE slices are acquired with different echo times (TE) and motion-corrected with slice-to-volume reconstruction (SVR). The quantitative T2 maps are obtained by a fit to a dictionary of simulated signals. The sequence is selected using simulated experiments on a numerical phantom and validated on a physical phantom scanned on a 1.5T system. In vivo quantitative T2 maps are obtained for five fetuses with gestational ages (GA) 21–35 weeks on the same 1.5T system.

The simulated experiments suggested that a TE of 400 ms combined with the clinically utilized TEs of 80 and 180 ms were most suitable for T2 measurements in the fetal brain. The validation on the physical phantom confirmed that the SS-FSE T2 measurements match the gold standard multi-echo spin echo measurements. We measured average T2s of around 200 and 280 ms in the fetal brain grey and white matter, respectively. This was slightly higher than fetal T2* and the neonatal T2 obtained from previous studies.

The motion-corrected SS-FSE acquisitions with varying TEs offer a promising practical framework for quantitative T2 measurements of the moving fetus.
Original languageEnglish
Pages (from-to)715-729
Number of pages15
JournalMagnetic resonance in medicine
Issue number2
Publication statusPublished - 16 Apr 2024


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