Abstract
Background And Aims: Although the epidemiology of stroke overall has been described, a more detailed and up to date analysis on intracerebral haemorrhage (ICH) epidemiology is required. We undertook a systematic review and meta-analysis of incidence, functional outcome and long-term survival of ICH.
Methods: Two investigators independently searched Ovid Medline database for population-based longitudinal studies of first-ever spontaneous ICH published from January 2000 to September 2019. Further eligible studies were identified from reference lists and advice from experts. Incidence, survival rate and functional outcome were extracted from studies. I-square was used to measure the inconsistency and random-effects model was used in all meta-analyses because of the heterogeneity.
Results: We identified 88 eligible studies, including 22,684 patients of 70,563,841 person-years. The global pooled ICH incidence was 27.98 per 100,000 person-years (95% confidence interval (CI): 23.24 to 33.69). The incidence rate varied from 3.09 to 341.8 per 100,000 person-years across studies. The pooled ICH incidence of European countries was 25.77 per 100,000 person-years (95% CI: 21.99 to 30.19). The pooled 1-year survival rate from 19 studies was 0.50 (95% CI: 0.41 to 0.6) and the pooled 5-year survival rate was 0.38 (95% CI: 0.30 to 0.47). The 5-year survival rate varies from 0.27 to 0.46. Six studies reported functional outcome with different measurements.
Conclusions: The pooled European incidence was lower than the worldwide incidence. Less than a half of ICH patients survived 1 year and less than two fifths survived 5 years. More research that estimate outcomes after stroke are needed.
Methods: Two investigators independently searched Ovid Medline database for population-based longitudinal studies of first-ever spontaneous ICH published from January 2000 to September 2019. Further eligible studies were identified from reference lists and advice from experts. Incidence, survival rate and functional outcome were extracted from studies. I-square was used to measure the inconsistency and random-effects model was used in all meta-analyses because of the heterogeneity.
Results: We identified 88 eligible studies, including 22,684 patients of 70,563,841 person-years. The global pooled ICH incidence was 27.98 per 100,000 person-years (95% confidence interval (CI): 23.24 to 33.69). The incidence rate varied from 3.09 to 341.8 per 100,000 person-years across studies. The pooled ICH incidence of European countries was 25.77 per 100,000 person-years (95% CI: 21.99 to 30.19). The pooled 1-year survival rate from 19 studies was 0.50 (95% CI: 0.41 to 0.6) and the pooled 5-year survival rate was 0.38 (95% CI: 0.30 to 0.47). The 5-year survival rate varies from 0.27 to 0.46. Six studies reported functional outcome with different measurements.
Conclusions: The pooled European incidence was lower than the worldwide incidence. Less than a half of ICH patients survived 1 year and less than two fifths survived 5 years. More research that estimate outcomes after stroke are needed.
| Original language | English |
|---|---|
| Article number | 02519/#1384 |
| Pages (from-to) | 653-653 |
| Journal | International Journal Of Stroke |
| Volume | 15 |
| Issue number | 1_suppl |
| DOIs | |
| Publication status | Published - 7 Nov 2020 |