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Incidence and patterns of abnormal corpus callosum in fetuses with isolated spina bifida aperta

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Yada Kunpalin, Jan Deprest, Ioannis Papastefanou, Emma Bredaki, Adalina Sacco, Francesca Russo, Jute Richter, Katrien Jansen, Sebastien Ourselin, Paolo De Coppi, Anna L. David, Fred Ushakov, Luc De Catte

Original languageEnglish
Pages (from-to)957-964
Number of pages8
JournalPrenatal Diagnosis
Volume41
Issue number8
DOIs
Accepted/In press2021
PublishedJul 2021

Bibliographical note

Funding Information: The authors acknowledge the support of Great Ormond Street Hospital Children's Charity, University College London Hospital Charity and the Elizabeth Garrett Anderson Hospital Charity for the Centre for Prenatal Therapy at UCLH. THe authors thank Dr. Timothy Edwards for reviewing the manuscript. Y. K. is supported through an Innovative Engineering for Health award by the Wellcome Trust (WT101957) and the Engineering and Physical Sciences Research Council (EPSRC) (NS/A000027/1). J. D. P. is supported by the Great Ormond Street Hospital Children's Charity. A. L. D. is supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. Funding Information: The authors acknowledge the support of Great Ormond Street Hospital Children's Charity, University College London Hospital Charity and the Elizabeth Garrett Anderson Hospital Charity for the Centre for Prenatal Therapy at UCLH. THe authors thank Dr. Timothy Edwards for reviewing the manuscript. Y. K. is supported through an Innovative Engineering for Health award by the Wellcome Trust (WT101957) and the Engineering and Physical Sciences Research Council (EPSRC) (NS/A000027/1). J. D. P. is supported by the Great Ormond Street Hospital Children's Charity. A. L. D. is supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. Publisher Copyright: © 2021 John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors

Abstract

Objective: To determine the incidence and characterise corpus callosum (CC) abnormalities in fetuses with spina bifida aperta (SBA) between 18 and 26 weeks of gestation. Methods: This was a retrospective study on fetuses with isolated SBA and who were assessed for fetal surgery. Digitally stored ultrasound images of the brain were reviewed for the presence/absence of the CC, and the length and diameter of its constituent parts (rostrum, genu, body and splenium). We used regression analysis to determine the relationship between CC abnormalities and gestational age, head circumference, ventricle size, lesion level and lesion type. Results: Nearly three-quarters of fetuses with isolated SBA had an abnormal CC (71.7%, 76/106). Partial agenesis was most common in the splenium (18.9%, 20/106) and the rostrum (13.2%, 14/106). The most common abnormal pattern was of a short CC with normal diameter throughout. Of note, 20.8% (22/106) had a hypoplastic genu and 28.3% (30/106) had a thick body part. Larger lateral ventricle size was associated with partial agenesis of the CC (odds ratio [OR]: 0.14, p < 0.001) and inversely associated with a shorter CC (OR: 2.60, p < 0.01). Conclusion: An abnormal CC is common in fetuses with isolated SBA who are referred for fetal surgery.

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