Increase of neuronal injury markers Tau and neurofilament light proteins in umbilical blood after intrapartum asphyxia

Hanna Toorell, Henrik Zetterberg, Kaj Blennow, Karin Sävman, Henrik Hagberg

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Aim: Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls.

Materials and methods: We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases.

Results: The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult.

Discussion: Future studies are warranted to support or refute the value of Tau/NFLin clinical practice.

Conclusion: Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJOURNAL OF MATERNAL FETAL AND NEONATAL MEDICINE
Early online date9 Jul 2017
DOIs
Publication statusE-pub ahead of print - 9 Jul 2017

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