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Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years

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Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years. / Fountoulakis, Nikolaos; Thakrar, Chiraag; Patel, Kishan; Viberti, Giancarlo; Gnudi, Luigi; Karalliedde, Janaka.

In: Journal of the American Heart Association, Vol. 6, No. 4, e004934, 04.2017.

Research output: Contribution to journalArticle

Harvard

Fountoulakis, N, Thakrar, C, Patel, K, Viberti, G, Gnudi, L & Karalliedde, J 2017, 'Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years', Journal of the American Heart Association, vol. 6, no. 4, e004934. https://doi.org/10.1161/JAHA.116.004934

APA

Fountoulakis, N., Thakrar, C., Patel, K., Viberti, G., Gnudi, L., & Karalliedde, J. (2017). Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years. Journal of the American Heart Association, 6(4), [e004934]. https://doi.org/10.1161/JAHA.116.004934

Vancouver

Fountoulakis N, Thakrar C, Patel K, Viberti G, Gnudi L, Karalliedde J. Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years. Journal of the American Heart Association. 2017 Apr;6(4). e004934. https://doi.org/10.1161/JAHA.116.004934

Author

Fountoulakis, Nikolaos ; Thakrar, Chiraag ; Patel, Kishan ; Viberti, Giancarlo ; Gnudi, Luigi ; Karalliedde, Janaka. / Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years. In: Journal of the American Heart Association. 2017 ; Vol. 6, No. 4.

Bibtex Download

@article{101d2eadeef04071a9a6e0406e639463,
title = "Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years",
abstract = "BACKGROUND: The objective of this study was to evaluate whether aortic pulse wave velocity (Ao-PWV) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus.METHODS AND RESULTS: This prospective single-center cohort study investigated 211 type 2 diabetes mellitus patients with eGFR ≥45 mL/min with a baseline mean age of 60.1 years (range, 30-82 years). The mean±SD baseline eGFR was 85±26.1 mL/min. We divided the cohort into 2 groups above (n=117, {"}older{"}) and below (n=94, {"}younger{"}) the mean age to evaluate whether Ao-PWV predicted progression of kidney disease differentially in older and younger patients. The primary end point was reaching a final eGFR below the median for the age group and an eGFR fall ≥1 mL/min per year. Median follow-up was 9 years (range, 3-11 years) and ≈50{\%} of patients in both groups reached the primary end point. In older patients, Ao-PWV was similar in those who did and did not reach the primary end point. By contrast, younger patients who reached the primary end point had a higher Ao-PWV at baseline compared with those who did not (10.8 m/s versus 9.5 m/s, respectively; mean difference of 1.36 m/s [95{\%} CI, 0.38-2.33], P=0.007). Ao-PWV was an independent predictor of the primary end point (incident risk ratio, 1.09; 95{\%} CI, 1.02-1.18) after adjustment for traditional risk factors only in younger patients (P=0.02). A 1m/s increase in Ao-PWV was associated with a mean fall in eGFR of 2.1 mL/min per year (95{\%} CI, 0.09-4.1) independent of other risk factors in younger patients (P=0.04).CONCLUSIONS: Ao-PWV predicts eGFR decline, before the onset of advanced renal dysfunction, and is a potential target for renoprotection in younger patients with type 2 diabetes mellitus.",
keywords = "Aortic stiffness, Arterial stiffness, Diabetes (kidney), Renal disease progression, Renal insufficiency, Type 2 diabetes mellitus",
author = "Nikolaos Fountoulakis and Chiraag Thakrar and Kishan Patel and Giancarlo Viberti and Luigi Gnudi and Janaka Karalliedde",
note = "{\circledC} 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.",
year = "2017",
month = "4",
doi = "10.1161/JAHA.116.004934",
language = "English",
volume = "6",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "American Heart Association, Inc.",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Increased Arterial Stiffness is an Independent Predictor of Renal Function Decline in Patients With Type 2 Diabetes Mellitus Younger Than 60 Years

AU - Fountoulakis, Nikolaos

AU - Thakrar, Chiraag

AU - Patel, Kishan

AU - Viberti, Giancarlo

AU - Gnudi, Luigi

AU - Karalliedde, Janaka

N1 - © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

PY - 2017/4

Y1 - 2017/4

N2 - BACKGROUND: The objective of this study was to evaluate whether aortic pulse wave velocity (Ao-PWV) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus.METHODS AND RESULTS: This prospective single-center cohort study investigated 211 type 2 diabetes mellitus patients with eGFR ≥45 mL/min with a baseline mean age of 60.1 years (range, 30-82 years). The mean±SD baseline eGFR was 85±26.1 mL/min. We divided the cohort into 2 groups above (n=117, "older") and below (n=94, "younger") the mean age to evaluate whether Ao-PWV predicted progression of kidney disease differentially in older and younger patients. The primary end point was reaching a final eGFR below the median for the age group and an eGFR fall ≥1 mL/min per year. Median follow-up was 9 years (range, 3-11 years) and ≈50% of patients in both groups reached the primary end point. In older patients, Ao-PWV was similar in those who did and did not reach the primary end point. By contrast, younger patients who reached the primary end point had a higher Ao-PWV at baseline compared with those who did not (10.8 m/s versus 9.5 m/s, respectively; mean difference of 1.36 m/s [95% CI, 0.38-2.33], P=0.007). Ao-PWV was an independent predictor of the primary end point (incident risk ratio, 1.09; 95% CI, 1.02-1.18) after adjustment for traditional risk factors only in younger patients (P=0.02). A 1m/s increase in Ao-PWV was associated with a mean fall in eGFR of 2.1 mL/min per year (95% CI, 0.09-4.1) independent of other risk factors in younger patients (P=0.04).CONCLUSIONS: Ao-PWV predicts eGFR decline, before the onset of advanced renal dysfunction, and is a potential target for renoprotection in younger patients with type 2 diabetes mellitus.

AB - BACKGROUND: The objective of this study was to evaluate whether aortic pulse wave velocity (Ao-PWV) predicts estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus.METHODS AND RESULTS: This prospective single-center cohort study investigated 211 type 2 diabetes mellitus patients with eGFR ≥45 mL/min with a baseline mean age of 60.1 years (range, 30-82 years). The mean±SD baseline eGFR was 85±26.1 mL/min. We divided the cohort into 2 groups above (n=117, "older") and below (n=94, "younger") the mean age to evaluate whether Ao-PWV predicted progression of kidney disease differentially in older and younger patients. The primary end point was reaching a final eGFR below the median for the age group and an eGFR fall ≥1 mL/min per year. Median follow-up was 9 years (range, 3-11 years) and ≈50% of patients in both groups reached the primary end point. In older patients, Ao-PWV was similar in those who did and did not reach the primary end point. By contrast, younger patients who reached the primary end point had a higher Ao-PWV at baseline compared with those who did not (10.8 m/s versus 9.5 m/s, respectively; mean difference of 1.36 m/s [95% CI, 0.38-2.33], P=0.007). Ao-PWV was an independent predictor of the primary end point (incident risk ratio, 1.09; 95% CI, 1.02-1.18) after adjustment for traditional risk factors only in younger patients (P=0.02). A 1m/s increase in Ao-PWV was associated with a mean fall in eGFR of 2.1 mL/min per year (95% CI, 0.09-4.1) independent of other risk factors in younger patients (P=0.04).CONCLUSIONS: Ao-PWV predicts eGFR decline, before the onset of advanced renal dysfunction, and is a potential target for renoprotection in younger patients with type 2 diabetes mellitus.

KW - Aortic stiffness

KW - Arterial stiffness

KW - Diabetes (kidney)

KW - Renal disease progression

KW - Renal insufficiency

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=85016616448&partnerID=8YFLogxK

U2 - 10.1161/JAHA.116.004934

DO - 10.1161/JAHA.116.004934

M3 - Article

C2 - 28360227

AN - SCOPUS:85016616448

VL - 6

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 4

M1 - e004934

ER -

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