Increased Collagen Synthesis Rate during Wound Healing in Muscle

TY - JOUR

T1 - Increased Collagen Synthesis Rate during Wound Healing in Muscle

AU - Zhou, Shaobo

AU - Salisbury, Jonathan

AU - Preedy, Victor R

AU - Emery, Peter W

PY - 2013

Y1 - 2013

N2 - Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.

AB - Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.

U2 - 10.1371/journal.pone.0058324

DO - 10.1371/journal.pone.0058324

M3 - Article

C2 - 23526975

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 3

M1 - e58324

ER -